| Literature DB >> 32290704 |
Yu-Bo Zhang1,2, Kar-Ho Lam1, Li-Feng Chen2, Hei Wan1, Guo-Cai Wang2, Kai-Fai Lee3, Chun-Wang Yip1, Kwun-Hung Liu1, Pak-Heng Leung4, Hai-Yong Chan1, Yi-Gang Shi1, Jia Zhao1, Li-Xing Lao1, Yao-Lan Li2, Yan-Bo Zhang1, Wei Meng1.
Abstract
A new aromatic glycoside (1) and a new natural product, neolignan (2), along with twenty-three known compounds (3-25), were isolated from the thorns of Gleditsia sinensis. According to the spectroscopic analyses (IR, UV, HRESIMS, NMR and ECD), the structures of isolates were elucidated. Herein, compounds 4, 6-8, 10-13, 15, 16, 18, 20, 23 were isolated from the plant of G. sinensis for the first time. Moreover, compounds 4, 6, 15 and 24 showed cytotoxic effects on human ovarian cancer (SKOV-3) cells with IC50 values of 24.83 ± 4.90, 48.86 ± 9.11, 80.13 ± 5.62, 15.38 ± 2.21 μM, respectively.[Formula: see text].Entities:
Keywords: Gleditsia sinensis; Leguminosae; chemical constituent; cytotoxic activity; structural identification
Year: 2020 PMID： 32290704 DOI： 10.1080/10286020.2020.1731799
Source DB: PubMed Journal: J Asian Nat Prod Res ISSN： 1028-6020 Impact factor: 1.569