Literature DB >> 32287073

Performing rapid autopsy for the interrogation of HIV reservoirs.

Stephen A Rawlings1, Laura Layman1, Davey Smith1,2, Brianna Scott1, Caroline Ignacio1, Magali Porrachia2, Susanna Concha-Garcia1, Steven Hendrickx1, Andy Kaytes3, Jeff Taylor3,4, Sara Gianella1,2.   

Abstract

: Rapid autopsy at the end of life in people with HIV (PWH) permits the preservation of valuable tissue specimens for subsequent study of HIV reservoirs. At our institution, we have developed a cohort of PWH who consent to a rapid autopsy to gather a wide range of fluids and tissues with the goal of advancing HIV cure research. The protocol for successfully performing these autopsies has required careful thought and development over months and years. We have now successfully performed six rapid autopsies and detail here our steps to build the study cohort, train and staff a team of more than a dozen personnel, and process and preserve hundreds of samples from each autopsy.

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Year:  2020        PMID： 32287073      PMCID： PMC7780881          DOI： 10.1097/QAD.0000000000002546

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.632


  12 in total

1.  Ethics guidelines for research with the recently dead.

Authors:  Rebecca D Pentz; Cynthia B Cohen; Mark Wicclair; Michael A DeVita; Anne Lederman Flamm; Stuart J Youngner; Ann B Hamric; Mary S McCabe; Jacqueline J Glover; Winona J Kittiko; Kathy Kinlaw; James Keller; Adrienne Asch; John J Kavanagh; Wadih Arap
Journal:  Nat Med       Date:  2005-11       Impact factor: 53.440

Review 2.  The challenge of finding a cure for HIV infection.

Authors:  Douglas D Richman; David M Margolis; Martin Delaney; Warner C Greene; Daria Hazuda; Roger J Pomerantz
Journal:  Science       Date:  2009-03-06       Impact factor: 47.728

Review 3.  Medical Assistance in Death as a Unique Opportunity to Advance Human Immunodeficiency Virus Cure Research.

Authors:  Teslin S Sandstrom; Stephanie C Burke Schinkel; Jonathan B Angel
Journal:  Clin Infect Dis       Date:  2019-08-30       Impact factor: 9.079

4.  Rapid ("warm") autopsy study for procurement of metastatic prostate cancer.

Authors:  M A Rubin; M Putzi; N Mucci; D C Smith; K Wojno; S Korenchuk; K J Pienta
Journal:  Clin Cancer Res       Date:  2000-03       Impact factor: 12.531

5.  Arizona Study of Aging and Neurodegenerative Disorders and Brain and Body Donation Program.

Authors:  Thomas G Beach; Charles H Adler; Lucia I Sue; Geidy Serrano; Holly A Shill; Douglas G Walker; LihFen Lue; Alex E Roher; Brittany N Dugger; Chera Maarouf; Alex C Birdsill; Anthony Intorcia; Megan Saxon-Labelle; Joel Pullen; Alexander Scroggins; Jessica Filon; Sarah Scott; Brittany Hoffman; Angelica Garcia; John N Caviness; Joseph G Hentz; Erika Driver-Dunckley; Sandra A Jacobson; Kathryn J Davis; Christine M Belden; Kathy E Long; Michael Malek-Ahmadi; Jessica J Powell; Lisa D Gale; Lisa R Nicholson; Richard J Caselli; Bryan K Woodruff; Steven Z Rapscak; Geoffrey L Ahern; Jiong Shi; Anna D Burke; Eric M Reiman; Marwan N Sabbagh
Journal:  Neuropathology       Date:  2015-01-26       Impact factor: 1.906

6.  Can research at the end of life be a useful tool to advance HIV cure?

Authors:  Sara Gianella; Jeff Taylor; Timothy R Brown; Andy Kaytes; Cristian L Achim; David J Moore; Susan J Little; Ronald J Ellis; Davey M Smith
Journal:  AIDS       Date:  2017-01-02       Impact factor: 4.177

7.  Altruism in terminal cancer patients and rapid tissue donation program: does the theory apply?

Authors:  Gwendolyn P Quinn; Devin Murphy; Christie Pratt; Teresita Muñoz-Antonia; Lucy Guerra; Matthew B Schabath; Marino E Leon; Eric Haura
Journal:  Med Health Care Philos       Date:  2013-11

8.  Recovery of replication-competent HIV despite prolonged suppression of plasma viremia.

Authors:  J K Wong; M Hezareh; H F Günthard; D V Havlir; C C Ignacio; C A Spina; D D Richman
Journal:  Science       Date:  1997-11-14       Impact factor: 47.728

9.  HIV persists throughout deep tissues with repopulation from multiple anatomical sources.

Authors:  Antoine Chaillon; Sara Gianella; Simon Dellicour; Stephen A Rawlings; Timothy E Schlub; Michelli Faria De Oliveira; Caroline Ignacio; Magali Porrachia; Bram Vrancken; Davey M Smith
Journal:  J Clin Invest       Date:  2020-04-01       Impact factor: 14.808

10.  Willingness to participate in HIV research at the end of life (EOL).

Authors:  Katya Prakash; Sara Gianella; Karine Dubé; Jeff Taylor; GaYoung Lee; Davey M Smith
Journal:  PLoS One       Date:  2018-07-23       Impact factor: 3.240
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  5 in total

1.  Tissue is the issue: how altruistic people with HIV are changing the HIV tissue reservoir landscape.

Authors:  Stephen A Rawlings; Sara Gianella
Journal:  Future Virol       Date:  2020-08-03       Impact factor: 1.831

Review 2.  Lessons for Understanding Central Nervous System HIV Reservoirs from the Last Gift Program.

Authors:  Patricia K Riggs; Antoine Chaillon; Guochun Jiang; Scott L Letendre; Yuyang Tang; Jeff Taylor; Andrew Kaytes; Davey M Smith; Karine Dubé; Sara Gianella
Journal:  Curr HIV/AIDS Rep       Date:  2022-10-19       Impact factor: 5.495

3.  Role of Tunneling Nanotube-like Structures during the Early Events of HIV Infection: Novel Features of Tissue Compartmentalization and Mechanism of HIV Spread.

Authors:  George Okafo; Silvana Valdebenito; Maribel Donoso; Ross Luu; David Ajasin; Brendan Prideaux; Santhi Gorantla; Eliseo A Eugenin
Journal:  J Immunol       Date:  2020-10-09       Impact factor: 5.422

4.  "My Death Will Not [Be] in Vain": Testimonials from Last Gift Rapid Research Autopsy Study Participants Living with HIV at the End of Life.

Authors:  Kelly E Perry; Karine Dubé; Susanna Concha-Garcia; Hursch Patel; Andy Kaytes; Jeff Taylor; Sogol Stephanie Javadi; Kushagra Mathur; Megan Lo; Brandon Brown; John A Sauceda; David A Wohl; Susan Little; Steven Hendrickx; Stephen A Rawlings; Davey M Smith; Sara Gianella
Journal:  AIDS Res Hum Retroviruses       Date:  2020-06-24       Impact factor: 2.205

5.  Attitudes and perceptions of next-of-kin/loved ones toward end-of-life HIV cure-related research: A qualitative focus group study in Southern California.

Authors:  Sogol S Javadi; Kushagra Mathur; Susanna Concha-Garcia; Hursch Patel; Kelly E Perry; Megan Lo; Jeff Taylor; Andy Kaytes; Susan Little; Sara Gianella; Davey Smith; Karine Dubé
Journal:  PLoS One       Date:  2021-05-07       Impact factor: 3.240
  5 in total

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