| Literature DB >> 32281387 |
Susanna L Lamers1, Rebecca Rose1, Sissy Cross1, Christopher W Rodriguez1, Andrew D Redd2,3, Thomas C Quinn2,3, David Serwadda4,5, Joseph Kagaayi5, Godfrey Kigozi5, Ronald Galiwango5, Ronald H Gray5,6, M Kate Grabowski3,5, Oliver Laeyendecker2,3.
Abstract
The Rakai Community Cohort Study in south central Uganda has surveyed people aged 15-49 since 1994. Antiretroviral therapy (ART) was introduced in 2004. HIV p24 and gp41 subtype distribution and viral diversity were studied from blood samples collected at three surveys in 1994-1995, 2002-2003, and 2008-2009, which were compared with a new survey round from 2011 to 2012. These included 1364 HIV+ individuals. For both p24 and gp41 domains, the genetic diversity within subtypes A and D was significantly increasing in the pre-ART era and decreased between the last two survey rounds in the ART era (p < .01). This study suggests that despite ongoing mixing of viral subtypes, an association with the introduction of ART to a reduction of intra-subtype viral genomic diversity may be occurring, which can be explored in ongoing studies.Entities:
Keywords: Uganda; sequence diversity; subtype change
Year: 2020 PMID： 32281387 PMCID： PMC7476391 DOI： 10.1089/AID.2020.0062
Source DB: PubMed Journal: AIDS Res Hum Retroviruses ISSN： 0889-2229 Impact factor: 2.205