Literature DB >> 32280435

Non-lethal growth inhibition by arresting the starch utilization system of clinically relevant human isolates of Bacteroides dorei.

Anthony D Santilli1, Jordan T Russell2, Eric W Triplett2, Kristi J Whitehead3, Daniel C Whitehead1.   

Abstract

We describe the inhibition of the starch utilization system (Sus) belonging to various strains of Bacteroides dorei in a non-lethal manner using the small molecule probe, acarbose. Concentrations of acarbose as low as 5 μM significantly impede the growth of B. dorei and increase the doubling time of cultures. The successful inhibition of this species of Bacteroides is relevant to several disease states including type I diabetes mellitus. This method continues to explore a new, potential route to intervene in illnesses associated with aberrant changes in the composition of the human gut microbiota through the strategic manipulation of its constituents. This journal is © The Royal Society of Chemistry 2019.

Entities:  

Year:  2019        PMID： 32280435      PMCID： PMC7120511          DOI： 10.1039/c9md00301k

Source DB:  PubMed          Journal:  Medchemcomm        ISSN： 2040-2503            Impact factor:   3.597


  33 in total

1.  Alterations in Intestinal Microbiota Correlate With Susceptibility to Type 1 Diabetes.

Authors:  Aimon K Alkanani; Naoko Hara; Peter A Gottlieb; Diana Ir; Charles E Robertson; Brandie D Wagner; Daniel N Frank; Danny Zipris
Journal:  Diabetes       Date:  2015-06-11       Impact factor: 9.461

2.  Nonmicrobicidal Small Molecule Inhibition of Polysaccharide Metabolism in Human Gut Microbes: A Potential Therapeutic Avenue.

Authors:  Anthony D Santilli; Elizabeth M Dawson; Kristi J Whitehead; Daniel C Whitehead
Journal:  ACS Chem Biol       Date:  2018-04-20       Impact factor: 5.100

3.  Bacteroides dorei sp. nov., isolated from human faeces.

Authors:  Mohammad Abdul Bakir; Mitsuo Sakamoto; Maki Kitahara; Mitsuharu Matsumoto; Yoshimi Benno
Journal:  Int J Syst Evol Microbiol       Date:  2006-07       Impact factor: 2.747

Review 4.  The role of the intestinal microbiota in type 1 diabetes mellitus.

Authors:  Mikael Knip; Heli Siljander
Journal:  Nat Rev Endocrinol       Date:  2016-01-04       Impact factor: 43.330

Review 5.  Current understanding of the role of gut dysbiosis in type 1 diabetes.

Authors:  Ahmed M Abdellatif; Nora E Sarvetnick
Journal:  J Diabetes       Date:  2019-04-22       Impact factor: 4.006

6.  Quantitative analysis of bacterial DNA from Mycobacteria spp., Bacteroides vulgatus, and Escherichia coli in tissue samples from patients with inflammatory bowel diseases.

Authors:  Hiroshi Fujita; Yoshinobu Eishi; Ikuo Ishige; Kiyoshi Saitoh; Touichirou Takizawa; Terukatsu Arima; Morio Koike
Journal:  J Gastroenterol       Date:  2002       Impact factor: 7.527

7.  Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans.

Authors:  Tommi Vatanen; Aleksandar D Kostic; Eva d'Hennezel; Heli Siljander; Eric A Franzosa; Moran Yassour; Raivo Kolde; Hera Vlamakis; Timothy D Arthur; Anu-Maaria Hämäläinen; Aleksandr Peet; Vallo Tillmann; Raivo Uibo; Sergei Mokurov; Natalya Dorshakova; Jorma Ilonen; Suvi M Virtanen; Susanne J Szabo; Jeffrey A Porter; Harri Lähdesmäki; Curtis Huttenhower; Dirk Gevers; Thomas W Cullen; Mikael Knip; Ramnik J Xavier
Journal:  Cell       Date:  2016-04-28       Impact factor: 41.582

8.  Bacteroides vulgatus outer membrane antigens associated with carrageenan-induced colitis in guinea pigs.

Authors:  J L Breeling; A B Onderdonk; R L Cisneros; D L Kasper
Journal:  Infect Immun       Date:  1988-07       Impact factor: 3.441

9.  Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes.

Authors:  Christopher T Brown; Austin G Davis-Richardson; Adriana Giongo; Kelsey A Gano; David B Crabb; Nabanita Mukherjee; George Casella; Jennifer C Drew; Jorma Ilonen; Mikael Knip; Heikki Hyöty; Riitta Veijola; Tuula Simell; Olli Simell; Josef Neu; Clive H Wasserfall; Desmond Schatz; Mark A Atkinson; Eric W Triplett
Journal:  PLoS One       Date:  2011-10-17       Impact factor: 3.240

10.  Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes.

Authors:  Austin G Davis-Richardson; Alexandria N Ardissone; Raquel Dias; Ville Simell; Michael T Leonard; Kaisa M Kemppainen; Jennifer C Drew; Desmond Schatz; Mark A Atkinson; Bryan Kolaczkowski; Jorma Ilonen; Mikael Knip; Jorma Toppari; Noora Nurminen; Heikki Hyöty; Riitta Veijola; Tuula Simell; Juha Mykkänen; Olli Simell; Eric W Triplett
Journal:  Front Microbiol       Date:  2014-12-10       Impact factor: 5.640
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  1 in total

Review 1.  First case of an invasive Bacteroides dorei infection detected in a patient with a mycotic aortic aneurysm-raising a rebellion of major indigenous bacteria in humans: a case report and review.

Authors:  Takayuki Matsuoka; Takuya Shimizu; Tadanori Minagawa; Wakiko Hiranuma; Miki Takeda; Risako Kakuta; Shunsuke Kawamoto
Journal:  BMC Infect Dis       Date:  2021-06-30       Impact factor: 3.090
  1 in total

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