Literature DB >> 29660284

Nonmicrobicidal Small Molecule Inhibition of Polysaccharide Metabolism in Human Gut Microbes: A Potential Therapeutic Avenue.

Anthony D Santilli1, Elizabeth M Dawson1, Kristi J Whitehead2, Daniel C Whitehead1.   

Abstract

A new approach for the nonmicrobicidal phenotypic manipulation of prominent gastrointestinal microbes is presented. Low micromolar concentrations of a chemical probe, acarbose, can selectively inhibit the Starch Utilization System and ablate the ability of Bacteroides thetaiotaomicron and B. fragilis strains to metabolize potato starch and pullulan. This strategy has potential therapeutic relevance for the selective modulation of the GI microbiota in a nonmicrobicidal manner.

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Year:  2018        PMID： 29660284     DOI： 10.1021/acschembio.8b00309

Source DB:  PubMed          Journal:  ACS Chem Biol        ISSN： 1554-8929            Impact factor:   5.100


  7 in total

1.  The human microbiome encodes resistance to the antidiabetic drug acarbose.

Authors:  Jared Balaich; Michael Estrella; Guojun Wu; Philip D Jeffrey; Abhishek Biswas; Liping Zhao; Alexei Korennykh; Mohamed S Donia
Journal:  Nature       Date:  2021-11-24       Impact factor: 69.504

2.  Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism.

Authors:  Shanshan Qiao; Chang Liu; Li Sun; Tao Wang; Huanqin Dai; Kai Wang; Li Bao; Hantian Li; Wenzhao Wang; Shuang-Jiang Liu; Hongwei Liu
Journal:  Nat Metab       Date:  2022-10-17

3.  Non-lethal growth inhibition by arresting the starch utilization system of clinically relevant human isolates of Bacteroides dorei.

Authors:  Anthony D Santilli; Jordan T Russell; Eric W Triplett; Kristi J Whitehead; Daniel C Whitehead
Journal:  Medchemcomm       Date:  2019-07-05       Impact factor: 3.597

Review 4.  Gut Microbiota and Their Neuroinflammatory Implications in Alzheimer's Disease.

Authors:  Vo Van Giau; Si Ying Wu; Angelo Jamerlan; Seong Soo A An; Sang Yun Kim; John Hulme
Journal:  Nutrients       Date:  2018-11-14       Impact factor: 5.717

5.  Changes in the gut microbiome and fermentation products concurrent with enhanced longevity in acarbose-treated mice.

Authors:  Byron J Smith; Richard A Miller; Aaron C Ericsson; David C Harrison; Randy Strong; Thomas M Schmidt
Journal:  BMC Microbiol       Date:  2019-06-13       Impact factor: 3.605

6.  The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome.

Authors:  Nielson T Baxter; Nicholas A Lesniak; Hamide Sinani; Patrick D Schloss; Nicole M Koropatkin
Journal:  mSphere       Date:  2019-02-06       Impact factor: 4.389

Review 7.  Microbial metabolites: cause or consequence in gastrointestinal disease?

Authors:  Serge Alain Fobofou; Tor Savidge
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2022-03-10       Impact factor: 4.871
  7 in total

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