Literature DB >> 32265506

The RESOLUTE consortium: unlocking SLC transporters for drug discovery.

Giulio Superti-Furga, Daniel Lackner, Tabea Wiedmer, Alvaro Ingles-Prieto, Barbara Barbosa, Enrico Girardi, Ulrich Goldmann, Bettina Gürtl, Kristaps Klavins, Christoph Klimek, Sabrina Lindinger, Eva Liñeiro-Retes, André C Müller, Svenja Onstein, Gregor Redinger, Daniela Reil, Vitaly Sedlyarov, Gernot Wolf, Matthew Crawford, Robert Everley, David Hepworth, Shenping Liu, Stephen Noell, Mary Piotrowski, Robert Stanton, Hui Zhang, Salvatore Corallino, Andrea Faedo, Maria Insidioso, Giovanna Maresca, Loredana Redaelli, Francesca Sassone, Lia Scarabottolo, Michela Stucchi, Paola Tarroni, Sara Tremolada, Helena Batoulis, Andreas Becker, Eckhard Bender, Yung-Ning Chang, Alexander Ehrmann, Anke Müller-Fahrnow, Vera Pütter, Diana Zindel, Bradford Hamilton, Martin Lenter, Diana Santacruz, Coralie Viollet, Charles Whitehurst, Kai Johnsson, Philipp Leippe, Birgit Baumgarten, Lena Chang, Yvonne Ibig, Martin Pfeifer, Jürgen Reinhardt, Julian Schönbett, Paul Selzer, Klaus Seuwen, Charles Bettembourg, Bruno Biton, Jörg Czech, Hélène de Foucauld, Michel Didier, Thomas Licher, Vincent Mikol, Antje Pommereau, Frédéric Puech, Veeranagouda Yaligara, Aled Edwards, Brandon J Bongers, Laura H Heitman, Ad P IJzerman, Huub J Sijben, Gerard J P van Westen, Justine Grixti, Douglas B Kell, Farah Mughal, Neil Swainston, Marina Wright-Muelas, Tina Bohstedt, Nicola Burgess-Brown, Liz Carpenter, Katharina Dürr, Jesper Hansen, Andreea Scacioc, Giulia Banci, Claire Colas, Daniela Digles, Gerhard Ecker, Barbara Füzi, Viktoria Gamsjäger, Melanie Grandits, Riccardo Martini, Florentina Troger, Patrick Altermatt, Cédric Doucerain, Franz Dürrenberger, Vania Manolova, Anna-Lena Steck, Hanna Sundström, Maria Wilhelm, Claire M Steppan.   

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Year:  2020        PMID： 32265506     DOI： 10.1038/d41573-020-00056-6

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


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  4 in total

Review 1.  SLC transporters as therapeutic targets: emerging opportunities.

Authors:  Lawrence Lin; Sook Wah Yee; Richard B Kim; Kathleen M Giacomini
Journal:  Nat Rev Drug Discov       Date:  2015-06-26       Impact factor: 84.694

2.  Discovery of a ZIP7 inhibitor from a Notch pathway screen.

Authors:  Erin Nolin; Sara Gans; Luis Llamas; Somnath Bandyopadhyay; Scott M Brittain; Paula Bernasconi-Elias; Kyle P Carter; Joseph J Loureiro; Jason R Thomas; Markus Schirle; Yi Yang; Ning Guo; Guglielmo Roma; Sven Schuierer; Martin Beibel; Alicia Lindeman; Frederic Sigoillot; Amy Chen; Kevin X Xie; Samuel Ho; John Reece-Hoyes; Wilhelm A Weihofen; Kayla Tyskiewicz; Dominic Hoepfner; Richard I McDonald; Nicolette Guthrie; Abhishek Dogra; Haibing Guo; Jian Shao; Jian Ding; Stephen M Canham; Geoff Boynton; Elizabeth L George; Zhao B Kang; Christophe Antczak; Jeffery A Porter; Owen Wallace; John A Tallarico; Amy E Palmer; Jeremy L Jenkins; Rishi K Jain; Simon M Bushell; Christy J Fryer
Journal:  Nat Chem Biol       Date:  2019-01-14       Impact factor: 15.040

3.  Chromopynones are pseudo natural product glucose uptake inhibitors targeting glucose transporters GLUT-1 and -3.

Authors:  George Karageorgis; Elena S Reckzeh; Javier Ceballos; Melanie Schwalfenberg; Sonja Sievers; Claude Ostermann; Axel Pahl; Slava Ziegler; Herbert Waldmann
Journal:  Nat Chem       Date:  2018-09-10       Impact factor: 24.427

4.  SLC19A1 transports immunoreactive cyclic dinucleotides.

Authors:  Rutger D Luteijn; Shivam A Zaver; Benjamin G Gowen; Stacia K Wyman; Nick E Garelis; Liberty Onia; Sarah M McWhirter; George E Katibah; Jacob E Corn; Joshua J Woodward; David H Raulet
Journal:  Nature       Date:  2019-09-11       Impact factor: 49.962
  4 in total
  17 in total

Review 1.  Current Chemical, Biological, and Physiological Views in the Development of Successful Brain-Targeted Pharmaceutics.

Authors:  Magdalena Markowicz-Piasecka; Agata Markiewicz; Patrycja Darłak; Joanna Sikora; Santosh Kumar Adla; Sreelatha Bagina; Kristiina M Huttunen
Journal:  Neurotherapeutics       Date:  2022-04-07       Impact factor: 6.088

Review 2.  An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters.

Authors:  Vojtech Dvorak; Tabea Wiedmer; Alvaro Ingles-Prieto; Patrick Altermatt; Helena Batoulis; Felix Bärenz; Eckhard Bender; Daniela Digles; Franz Dürrenberger; Laura H Heitman; Adriaan P IJzerman; Douglas B Kell; Stefanie Kickinger; Daniel Körzö; Philipp Leippe; Thomas Licher; Vania Manolova; Riccardo Rizzetto; Francesca Sassone; Lia Scarabottolo; Avner Schlessinger; Vanessa Schneider; Hubert J Sijben; Anna-Lena Steck; Hanna Sundström; Sara Tremolada; Maria Wilhelm; Marina Wright Muelas; Diana Zindel; Claire M Steppan; Giulio Superti-Furga
Journal:  Front Pharmacol       Date:  2021-08-10       Impact factor: 5.988

3.  Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies.

Authors:  Sook Wah Yee; Dina Buitrago; Adrian Stecula; Huy X Ngo; Huan-Chieh Chien; Ling Zou; Megan L Koleske; Kathleen M Giacomini
Journal:  FASEB J       Date:  2020-10-30       Impact factor: 5.191

4.  The Biology of Lactoferrin, an Iron-Binding Protein That Can Help Defend Against Viruses and Bacteria.

Authors:  Douglas B Kell; Eugene L Heyden; Etheresia Pretorius
Journal:  Front Immunol       Date:  2020-05-28       Impact factor: 7.561

5.  Exploiting the metabolic dependencies of the broad amino acid transporter SLC6A14.

Authors:  Francesca R Dejure; Joachim Butzer; Ralph K Lindemann; Balca R Mardin
Journal:  Oncotarget       Date:  2020-12-01

6.  Structural Similarities between Some Common Fluorophores Used in Biology, Marketed Drugs, Endogenous Metabolites, and Natural Products.

Authors:  Steve O'Hagan; Douglas B Kell
Journal:  Mar Drugs       Date:  2020-11-23       Impact factor: 5.118

7.  Yeast Double Transporter Gene Deletion Library for Identification of Xenobiotic Carriers in Low or High Throughput.

Authors:  Ludimila Dias Almeida; Ali Salim Faraj Silva; Daniel Calixto Mota; Adrielle Ayumi Vasconcelos; Antônio Pedro Camargo; Gabriel Silva Pires; Monique Furlan; Helena Martins Ribeiro da Cunha Freire; Angélica Hollunder Klippel; Suélen Fernandes Silva; Cleslei Fernando Zanelli; Marcelo Falsarella Carazzolle; Stephen G Oliver; Elizabeth Bilsland
Journal:  mBio       Date:  2021-12-14       Impact factor: 7.786

8.  A substrate-based ontology for human solute carriers.

Authors:  Eva Meixner; Ulrich Goldmann; Vitaly Sedlyarov; Stefania Scorzoni; Manuele Rebsamen; Enrico Girardi; Giulio Superti-Furga
Journal:  Mol Syst Biol       Date:  2020-07       Impact factor: 11.429

9.  An untargeted metabolomics strategy to measure differences in metabolite uptake and excretion by mammalian cell lines.

Authors:  Marina Wright Muelas; Ivayla Roberts; Farah Mughal; Steve O'Hagan; Philip J Day; Douglas B Kell
Journal:  Metabolomics       Date:  2020-10-07       Impact factor: 4.290

Review 10.  The Transporter-Mediated Cellular Uptake and Efflux of Pharmaceutical Drugs and Biotechnology Products: How and Why Phospholipid Bilayer Transport Is Negligible in Real Biomembranes.

Authors:  Douglas B Kell
Journal:  Molecules       Date:  2021-09-16       Impact factor: 4.411
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