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Literature DB >> 3226468

Changes of mitochondrial membrane proteins in rat cerebellum during aging.

L Turpeenoja¹, R F Villa, G Magri, A M Giuffrida Stella.

Abstract

Qualitative and quantitative changes of mitochondrial membrane proteins during aging were investigated. Free (non-synaptic) mitochondria were purified from rat cerebellum at different ages (4, 8, 12, 16, 20, and 24 months). Mitochondrial outer membrane (OM), inner membrane (IM) and matrix (MX) were separated and the proteins were extracted and analyzed by gel-electrophoresis. After staining, the gels were scanned densitometrically to quantify the proteins. No significant changes in the quantity of OM or MX protein subunits were observed, while several statistically significant quantitative changes in IM proteins with age were found. These age-dependent modifications of inner membrane mitochondrial proteins may play an important role in energy transduction, transport systems and regulatory enzymatic activities in mitochondria.

Entities: Species

Mesh：

Substances：
Membrane Proteins

Year: 1988 PMID： 3226468 DOI： 10.1007/bf00970754

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

23 in total

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14 in total

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2. Effect of ageing and ischemia on enzymatic activities linked to Krebs' cycle, electron transfer chain, glutamate and aminoacids metabolism of free and intrasynaptic mitochondria of cerebral cortex.

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