Literature DB >> 2747833

Age-dependent modifications of mitochondrial proteins in cerebral cortex and striatum of rat brain.

N Ragusa1, L Turpeenoja, G Magri, P Lähdesmäki, A M Giuffrida Stella.   

Abstract

The protein composition of free mitochondria purified from cerebral cortex and striatum during aging was analyzed by gel electrophoresis. Mitochondria were isolated from cerebral cortex and striatum of 4-, 12-, and 24-month-old rat brain. The percent amount of mitochondrial proteins after gel-electrophoretic separation was determined densitometrically. A significant decrease in the amount of two polypeptides (with molecular weights of 20 and 16 kDa, respectively) in both brain regions during aging was found. The decrease was higher in the striatum indicating a greater vulnerability of this brain area to the aging process. The age-dependent modifications of mitochondrial proteins observed may play an important role in several mitochondrial functions, such as energy transduction and transport processes as well as in structural changes occurring with age, causing altered membrane permeability and fluidity.

Entities:  

Mesh：

Year:  1989        PMID： 2747833     DOI： 10.1007/bf00964854

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  19 in total

1.  Cholinergic and non-cholinergic nerve endings in rat brain. I. Isolation and subcellular distribution of acetylcholine and acetylcholinesterase.

Authors:  E DE ROBERTIS; A PELLEGRINO DE IRALDI; G RODRIGUEZ DE LORES GARNAIZ; L SALGANICOFF
Journal:  J Neurochem       Date:  1962 Jan-Feb       Impact factor: 5.372

2.  Age-related changes in cytochrome concentration of myocardial mitochondria.

Authors:  G M Abu-Erreish; D R Sanadi
Journal:  Mech Ageing Dev       Date:  1978-06       Impact factor: 5.432

3.  Regional and cellular differences in rat brain protein synthesis in vivo and in slices during development.

Authors:  F M Shahbazian; M Jacobs; A Lajtha
Journal:  Int J Dev Neurosci       Date:  1986       Impact factor: 2.457

4.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

5.  Developmental effects on protein synthesis rates in regions of the CNS in vivo and in vitro.

Authors:  D S Dunlop; W van Elden; A Lajtha
Journal:  J Neurochem       Date:  1977-12       Impact factor: 5.372

6.  Aging-dependent modification of lipid composition and lipid structural order parameter of hepatic mitochondria.

Authors:  M L Vorbeck; A P Martin; J W Long; J M Smith; R R Orr
Journal:  Arch Biochem Biophys       Date:  1982-08       Impact factor: 4.013

7.  Regional analysis of rat brain proteins during senescence.

Authors:  J W Cosgrove; J R Atack; S I Rapoport
Journal:  Exp Gerontol       Date:  1987       Impact factor: 4.032

8.  Myocardial protein synthesis during aging and endurance exercise in rats.

Authors:  J W Starnes; D W Edington; R E Beyer
Journal:  J Gerontol       Date:  1983-11

9.  Rat brain protein synthesis declines during postdevelopmental aging.

Authors:  B E Dwyer; J L Fando; C G Wasterlain
Journal:  J Neurochem       Date:  1980-09       Impact factor: 5.372

10.  Age-dependent changes in brain protein synthesis in the rat.

Authors:  J L Fando; M Salinas; C G Wasterlain
Journal:  Neurochem Res       Date:  1980-04       Impact factor: 3.996
View more
  6 in total

1.  Action of L-acetylcarnitine on different cerebral mitochondrial populations from hippocampus and striatum during aging.

Authors:  R F Villa; A Gorini
Journal:  Neurochem Res       Date:  1991-10       Impact factor: 3.996

2.  Changes of mitochondrial cytochrome c oxidase and FoF1 ATP synthase subunits in rat cerebral cortex during aging.

Authors:  V G Nicoletti; E A Tendi; C Lalicata; S Reale; A Costa; R F Villa; N Ragusa; A M Giuffrida Stella
Journal:  Neurochem Res       Date:  1995-12       Impact factor: 3.996

3.  Cerebral cortex synaptic heavy mitochondria may represent the oldest synaptic mitochondrial population: biochemical heterogeneity and effects of L-acetylcarnitine.

Authors:  M Battino; J L Quiles; J R Huertas; J F Mataix; R F Villa; A Gorini
Journal:  J Bioenerg Biomembr       Date:  2000-04       Impact factor: 2.945

4.  Effect of in vivo L-acetylcarnitine administration on ATP-ases enzyme systems of synaptic plasma membranes from rat cerebral cortex.

Authors:  Roberto Federico Villa; Federica Ferrari; Antonella Gorini
Journal:  Neurochem Res       Date:  2011-04-09       Impact factor: 3.996

5.  Action of L-acetylcarnitine on different cerebral mitochondrial populations from cerebral cortex.

Authors:  A Gorini; A D'Angelo; R F Villa
Journal:  Neurochem Res       Date:  1998-12       Impact factor: 3.996

6.  Effect of hypoxia on mitochondrial protein composition of cerebral cortex during aging.

Authors:  R F Villa; L Turpeenoja; G Magrì; A Gorini; N Ragusa; A M Giuffrida-Stella
Journal:  Neurochem Res       Date:  1991-07       Impact factor: 3.996
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.