| Literature DB >> 32251703 |
Monika Kaushik Siddharth Manvati1, Juveria Khan1, Neeraj Verma1, Pawan K Dhar2.
Abstract
MicroRNAs (miRNAs) are small non-coding RNA molecules of around 22 nucleotides in length. They are crucially involved in the post transcriptional regulation and thus play a significant role in the modulation of different diseases. Several studies have suggested that miRNA expression is dysregulated in various cancers through different mechanisms and the dysregulated miRNA in return affects different cancer hallmarks including cell proliferation, cell death suppression, metastasis and angiogenesis. Compilation of the available miRNA data can be a stimulator for proper understanding of the correlation between the miRNA expression and cancer progression. In this review, we have focussed on the role of miR-760 in the progression of different cancer. MicroRNA-760 (miR-760) has been found to be down regulated in various cancers, thus it can be utilized as a possible prognostic marker for cancer detection. Here, we have tried to fill a gap regarding the role of miR-760 in relation to cervical cancer also. Moreover, unravelling the role of miR-760 in different cancers will enlighten the researchers with proper understanding of biology of miR-760 in regulation of different cancers.Entities:
Keywords: Cancer; Non-coding DNA; Regulation; miR-760; micro RNA; microRNA targets
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Year: 2020 PMID: 32251703 DOI: 10.1016/j.gene.2020.144648
Source DB: PubMed Journal: Gene ISSN: 0378-1119 Impact factor: 3.688