Hagar Elghazawy1,2, Azza Nasr1,3, Iman Zaky1,4, Manal Zamzam1,5, Ahmed Elgammal1,5, Nesma Farid6, Mohamed S Zaghloul1,3. 1. Children's Cancer Hospital, Egypt (CCHE), Cairo, Egypt. 2. Department of Clinical Oncology, Ain Shams University, Cairo, Egypt. 3. Department of Radiotherapy, National Cancer Institute, Cairo University, Cairo, Egypt. 4. Department of Radiodiagnosis, National Cancer Institute, Cairo University, Cairo, Egypt. 5. Department of Pediatric Oncology, National Cancer Institute, Cairo University, Cairo, Egypt. 6. Department of Research, Children's Cancer Hospital, Egypt (CCHE), Cairo, Egypt.
Abstract
Aim: Scarce data assessing the real value of whole lung irradiation (WLI) in Ewing's sarcoma (ES) with lung-only metastasis, with published conflicting results. We studied the impact of WLI in a homogenous pediatric population. Materials & methods: Retrospective study evaluating the survival outcomes of WLI in these patients. Results: Out of 163 metastatic ES; 41 patients were eligible for WLI. 30 patients (73.1%) received WLI (+ve) while 11 patients (26.8%) did not receive WLI (-ve). Five-year event-free survival was statistically significant in WLI (+ve). Five-year pulmonary relapse-free survival showed trend for improvement with WLI (+ve), while 5-year overall survival was not statistically significant between the two arms. Conclusion: WLI added significantly to the long term clinical outcome of metastatic ES patients, with no irreversible toxicity.
Aim: Scarce data assessing the real value of whole lung irradiation (WLI) in Ewing's sarcoma (ES) with lung-only metastasis, with published conflicting results. We studied the impact of WLI in a homogenous pediatric population. Materials & methods: Retrospective study evaluating the survival outcomes of WLI in these patients. Results: Out of 163 metastatic ES; 41 patients were eligible for WLI. 30 patients (73.1%) received WLI (+ve) while 11 patients (26.8%) did not receive WLI (-ve). Five-year event-free survival was statistically significant in WLI (+ve). Five-year pulmonary relapse-free survival showed trend for improvement with WLI (+ve), while 5-year overall survival was not statistically significant between the two arms. Conclusion:WLI added significantly to the long term clinical outcome of metastatic ESpatients, with no irreversible toxicity.
Authors: Gregory C Stachelek; John A Ligon; Jennifer Vogel; Adam S Levin; Nicolas J Llosa; Brian H Ladle; Christian F Meyer; Stephanie A Terezakis; Carol D Morris; Matthew M Ladra; Christine A Pratilas Journal: Sarcoma Date: 2021-04-17