Theodore A Gobillot1,2, Caroline Kikawa1, Dara A Lehman1,3, John Kinuthia4,5, Alison L Drake3, Walter Jaoko6, Kishorchandra Mandaliya7, Grace John-Stewart3,8,9, R Scott McClelland3,8,9, Julie Overbaugh1. 1. Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. 2. Medical Scientist Training Program, University of Washington School of Medicine, Seattle, Washington, USA. 3. Department of Global Health, University of Washington, Seattle, Washington, USA. 4. Research and Programs, Kenyatta National Hospital, Nairobi, Kenya. 5. Reproductive Health, Kenyatta National Hospital, Nairobi, Kenya. 6. Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya. 7. University of Nairobi Institute of Tropical & Infectious Diseases, Nairobi, Kenya. 8. Department of Epidemiology, University of Washington, Seattle, Washington, USA. 9. Department of Medicine, University of Washington, Seattle, Washington, USA.
Abstract
BACKGROUND: Zika virus (ZIKV) was discovered over 70 years ago in East Africa, but little is known about its circulation and pathogenesis there. METHODS: We screened 327 plasma samples collected 2-12 months after febrile illness in Western and coastal Kenya (1993-2016) for binding and neutralizing antibodies to distinguish ZIKV and dengue virus (DENV) responses, which we found were common in coastal Kenya. RESULTS: Two cases had durable ZIKV-specific antibodies and 2 cases had ZIKV antibodies at similar levels as DENV antibodies. CONCLUSIONS: This suggests low-level ZIKV circulation in Kenya over 2 decades and sets a baseline for future surveillance efforts in East Africa.
BACKGROUND:Zika virus (ZIKV) was discovered over 70 years ago in East Africa, but little is known about its circulation and pathogenesis there. METHODS: We screened 327 plasma samples collected 2-12 months after febrile illness in Western and coastal Kenya (1993-2016) for binding and neutralizing antibodies to distinguish ZIKV and dengue virus (DENV) responses, which we found were common in coastal Kenya. RESULTS: Two cases had durable ZIKV-specific antibodies and 2 cases had ZIKV antibodies at similar levels as DENV antibodies. CONCLUSIONS: This suggests low-level ZIKV circulation in Kenya over 2 decades and sets a baseline for future surveillance efforts in East Africa.
Authors: John Timothy Kayiwa; Annet Martha Nankya; Irene Joyce Ataliba; Eric C Mossel; Mary B Crabtree; Julius Julian Lutwama Journal: J Gen Virol Date: 2018-07-05 Impact factor: 3.891
Authors: Mark R Duffy; Tai-Ho Chen; W Thane Hancock; Ann M Powers; Jacob L Kool; Robert S Lanciotti; Moses Pretrick; Maria Marfel; Stacey Holzbauer; Christine Dubray; Laurent Guillaumot; Anne Griggs; Martin Bel; Amy J Lambert; Janeen Laven; Olga Kosoy; Amanda Panella; Brad J Biggerstaff; Marc Fischer; Edward B Hayes Journal: N Engl J Med Date: 2009-06-11 Impact factor: 91.245
Authors: M Kariuki Njenga; L Nderitu; J P Ledermann; A Ndirangu; C H Logue; C H L Kelly; R Sang; K Sergon; R Breiman; A M Powers Journal: J Gen Virol Date: 2008-11 Impact factor: 3.891
Authors: Magelda Montoya; Matthew Collins; Wanwisa Dejnirattisai; Leah C Katzelnick; Henry Puerta-Guardo; Ramesh Jadi; Samuel Schildhauer; Piyada Supasa; Sirijitt Vasanawathana; Prida Malasit; Juthathip Mongkolsapaya; Aruna D de Silva; Hasitha Tissera; Angel Balmaseda; Gavin Screaton; Aravinda M de Silva; Eva Harris Journal: J Infect Dis Date: 2018-07-13 Impact factor: 5.226
Authors: Esther M Ellis; John C Neatherlin; Mark Delorey; Melvin Ochieng; Abdinoor Haji Mohamed; Daniel Ondari Mogeni; Elizabeth Hunsperger; Shem Patta; Stella Gikunju; Lilian Waiboic; Barry Fields; Victor Ofula; Samson Limbaso Konongoi; Brenda Torres-Velasquez; Nina Marano; Rosemary Sang; Harold S Margolis; Joel M Montgomery; Kay M Tomashek Journal: PLoS Negl Trop Dis Date: 2015-04-29
Authors: Vanessa Salazar; Brett W Jagger; Juthathip Mongkolsapaya; Katherine E Burgomaster; Wanwisa Dejnirattisai; Emma S Winkler; Estefania Fernandez; Christopher A Nelson; Daved H Fremont; Theodore C Pierson; James E Crowe; Gavin R Screaton; Michael S Diamond Journal: Cell Rep Date: 2019-02-05 Impact factor: 9.423
Authors: Sarah C Hill; Jocelyne Vasconcelos; Zoraima Neto; Domingos Jandondo; Líbia Zé-Zé; Renato Santana Aguiar; Joilson Xavier; Julien Thézé; Marinela Mirandela; Ana Luísa Micolo Cândido; Filipa Vaz; Cruz Dos Santos Sebastião; Chieh-Hsi Wu; Moritz U G Kraemer; Adriana Melo; Bruno L F Schamber-Reis; Girlene S de Azevedo; Amilcar Tanuri; Luiza M Higa; Carina Clemente; Sara Pereira da Silva; Darlan da Silva Candido; Ingra M Claro; Domingos Quibuco; Cristóvão Domingos; Bárbara Pocongo; Alexander G Watts; Kamran Khan; Luiz Carlos Junior Alcantara; Ester C Sabino; Eve Lackritz; Oliver G Pybus; Maria-João Alves; Joana Afonso; Nuno R Faria Journal: Lancet Infect Dis Date: 2019-10 Impact factor: 25.071
Authors: Isamu Tsuji; Fue Vang; David Dominguez; Lovkesh Karwal; Ankita Sanjali; Jill A Livengood; Edgar Davidson; Mallorie E Fouch; Benjamin J Doranz; Subash C Das; Hansi J Dean Journal: J Virol Date: 2022-05-16 Impact factor: 6.549
Authors: Eric Osoro; Irene Inwani; Cyrus Mugo; Elizabeth Hunsperger; Jennifer R Verani; Victor Omballa; Dalton Wamalwa; Chulwoo Rhee; Ruth Nduati; John Kinuthia; Hafsa Jin; Lydia Okutoyi; Dufton Mwaengo; Brian Maugo; Nancy A Otieno; Harriet Mirieri; Mufida Shabibi; Peninah Munyua; M Kariuki Njenga; Marc-Alain Widdowson Journal: BMC Med Date: 2022-09-14 Impact factor: 11.150