| Literature DB >> 32241179 |
Gea Kõks1, Ele Prans2, Xuan D Ho3, Binh H Duy3, Ha Dt Tran4, Ngoc Bt Ngo4, Linh Nn Hoang4, Hue Mt Tran4, Vivien J Bubb5, John P Quinn5, Sulev Kõks6,7.
Abstract
IMPACT STATEMENT: The present study combined the analysis of two transcriptional regulators, uVNTR and dVNTR, in the MAOA gene that is an enzyme responsible for the monoamine degradation and identified genetic interaction between these VNTRs in association with the nicotine dependence. The main impact is that when analyzing different populations in the genetic studies, the functionally meaningful variants should be combined rather than addressing individual elements separately (a mini polygenic risk score for a particular gene/locus). This combination is very rarely analyzed and therefore the study sets an example. Another impact is that we analyzed the genetic variability in the Asian population and therefore our data present a piece of information from underrepresented populations.Entities:
Keywords: Fagerström Test for Nicotine Dependence; MAOA; Variable number tandem repeat; Vietnam; genetic interaction; nicotine dependence; smoking; stratification
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Year: 2020 PMID： 32241179 PMCID： PMC7221489 DOI： 10.1177/1535370220916888
Source DB: PubMed Journal: Exp Biol Med (Maywood) ISSN： 1535-3699