Literature DB >> 3223918

Conserved region of the rat alpha-lactalbumin promoter is a target site for protein binding in vitro.

H Lubon1, L Hennighausen.   

Abstract

Nuclear extracts from mammary glands of lactating rats contain DNA binding protein(s) with high affinity to the region -125 to -85 of the rat alpha-lactalbumin promoter. The protected sequence is part of a mammary conserved sequence described by Hall et al. [(1987) Biochem. J. 242, 735-742]. Comparison of the DNA protein-binding sites in the 5' flanking sequence of the rat alpha-lactalbumin and mouse whey acidic protein genes suggests that the consensus sequence 5'-TGGCARNNWCKKC-3' is the protein(s) recognition site. This binding site is part of a highly conserved region [consensus sequence, TGGCAGSCTCGGCST(G)YTCTCTCT(NTG)TGGCARA] present in the promoter of four whey protein genes.

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Year:  1988        PMID： 3223918      PMCID： PMC1135422          DOI： 10.1042/bj2560391

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  32 in total

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Authors:  K F Lee; F J DeMayo; S H Atiee; J M Rosen
Journal:  Nucleic Acids Res       Date:  1988-02-11       Impact factor: 16.971

3.  The rat casein multigene family. Fine structure and evolution of the beta-casein gene.

Authors:  W K Jones; L Y Yu-Lee; S M Clift; T L Brown; J M Rosen
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4.  Similarity of the nucleotide sequences of rat alpha-lactalbumin and chicken lysozyme genes.

Authors:  P K Qasba; S K Safaya
Journal:  Nature       Date:  1984 Mar 22-28       Impact factor: 49.962

5.  Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.

Authors:  J D Dignam; R M Lebovitz; R G Roeder
Journal:  Nucleic Acids Res       Date:  1983-03-11       Impact factor: 16.971

6.  Comparison of the whey acidic protein genes of the rat and mouse.

Authors:  S M Campbell; J M Rosen; L G Hennighausen; U Strech-Jurk; A E Sippel
Journal:  Nucleic Acids Res       Date:  1984-11-26       Impact factor: 16.971

7.  The study of differentiative potential of the lactating mouse mammary gland in organ culture.

Authors:  J W Perry; T Oka
Journal:  In Vitro       Date:  1984-01

8.  Interaction of mouse mammary epithelial cells with collagen substrata: regulation of casein gene expression and secretion.

Authors:  E Y Lee; W H Lee; C S Kaetzel; G Parry; M J Bissell
Journal:  Proc Natl Acad Sci U S A       Date:  1985-03       Impact factor: 11.205

9.  The interaction of cortisol and prostaglandins on the phenotypic expression of the alpha-lactalbumin gene in the mouse mammary gland in culture.

Authors:  N Terada; L J Leiderman; T Oka
Journal:  Biochem Biophys Res Commun       Date:  1983-03-29       Impact factor: 3.575

10.  Targeted c-myc gene expression in mammary glands of transgenic mice induces mammary tumours with constitutive milk protein gene transcription.

Authors:  C A Schoenenberger; A C Andres; B Groner; M van der Valk; M LeMeur; P Gerlinger
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  10 in total

Review 1.  Beta1,4-galactosyltransferase and lactose biosynthesis: recruitment of a housekeeping gene from the nonmammalian vertebrate gene pool for a mammary gland specific function.

Authors:  N L Shaper; M Charron; N W Lo; J H Shaper
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Authors:  Janice Murtagh; Finian Martin; Richard M Gronostajski
Journal:  J Mammary Gland Biol Neoplasia       Date:  2003-04       Impact factor: 2.673

3.  Transcriptional regulation of alpha(1b) adrenergic receptors (alpha(1b)AR) by nuclear factor 1 (NF1): a decline in the concentration of NF1 correlates with the downregulation of alpha(1b)AR gene expression in regenerating liver.

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Journal:  Mol Cell Biol       Date:  1996-11       Impact factor: 4.272

4.  kappa B elements strongly activate gene expression in non-lymphoid cells and function synergistically with NF1 elements.

Authors:  L Hennighausen; P A Furth; C W Pittius
Journal:  Nucleic Acids Res       Date:  1989-10-25       Impact factor: 16.971

5.  Exon organization and sequence of the genes encoding alpha-lactalbumin and beta-lactoglobulin from the tammar wallaby (Macropodidae, Marsupialia).

Authors:  C Collet; R Joseph
Journal:  Biochem Genet       Date:  1995-02       Impact factor: 1.890

6.  Position-independent expression of the ovine beta-lactoglobulin gene in transgenic mice.

Authors:  C B Whitelaw; S Harris; M McClenaghan; J P Simons; A J Clark
Journal:  Biochem J       Date:  1992-08-15       Impact factor: 3.857

7.  Interaction of DNA-binding proteins with a milk protein gene promoter in vitro: identification of a mammary gland-specific factor.

Authors:  C J Watson; K E Gordon; M Robertson; A J Clark
Journal:  Nucleic Acids Res       Date:  1991-12-11       Impact factor: 16.971

8.  A mammary cell-specific enhancer in mouse mammary tumor virus DNA is composed of multiple regulatory elements including binding sites for CTF/NFI and a novel transcription factor, mammary cell-activating factor.

Authors:  S Mink; E Härtig; P Jennewein; W Doppler; A C Cato
Journal:  Mol Cell Biol       Date:  1992-11       Impact factor: 4.272

9.  Regulation of human protein C gene expression by the mouse WAP promoter.

Authors:  R K Paleyanda; D W Zhang; L Hennighausen; R A McKnight; H Lubon
Journal:  Transgenic Res       Date:  1994-11       Impact factor: 2.788

Review 10.  A Comparative Review of the Extrinsic and Intrinsic Factors Regulating Lactose Synthesis.

Authors:  Anna Sadovnikova; Sergio C Garcia; Russell C Hovey
Journal:  J Mammary Gland Biol Neoplasia       Date:  2021-06-14       Impact factor: 2.673
  10 in total

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