Giulio Ferrari1, Paolo Rama2. 1. San Raffaele Hospital, Cornea and Ocular Surface Unit, Eye Repair Lab, Italy. Electronic address: ferrari.giulio@hsr.it. 2. San Raffaele Hospital, Cornea and Ocular Surface Unit, Eye Repair Lab, Italy.
Abstract
PURPOSE: To review the literature on the etiopathogenesis of keratoconus (KC). METHODS: A literature search was conducted using PUBMED and Google Scholar for keratoconus. The authors analyzed epidemiology studies, reviews, and case reports. RESULTS: Atopy and ocular surface inflammation are a common features of KC and should lead to a reconsideration of the traditional definition of KC as a "non inflammatory" condition. Co-morbidities suggest that KC may be the ocular manifestation of a systemic disease. Finally, KC shows higher prevalence in certain ethnicities, which calls into question the status of KC as a rare disease, at least in these communities. CONCLUSION: We believe that future studies should test whether selected, high prevalence populations exhibit specific genetic background and/or ethno-specific environmental risk factors.
PURPOSE: To review the literature on the etiopathogenesis of keratoconus (KC). METHODS: A literature search was conducted using PUBMED and Google Scholar for keratoconus. The authors analyzed epidemiology studies, reviews, and case reports. RESULTS: Atopy and ocular surface inflammation are a common features of KC and should lead to a reconsideration of the traditional definition of KC as a "non inflammatory" condition. Co-morbidities suggest that KC may be the ocular manifestation of a systemic disease. Finally, KC shows higher prevalence in certain ethnicities, which calls into question the status of KC as a rare disease, at least in these communities. CONCLUSION: We believe that future studies should test whether selected, high prevalence populations exhibit specific genetic background and/or ethno-specific environmental risk factors.
Authors: Le Chang; Lin Zhang; Zhenzhou Cheng; Nan Zhang; Congzheng Wang; Yan Wang; Weiwei Liu Journal: Biomed Opt Express Date: 2022-09-01 Impact factor: 3.562
Authors: Ana Filipa Moleiro; Ana Francisca Aires; Hélio Alves; João Viana Pinto; Ângela Carneiro; Fernando Falcão-Reis; Luís Figueira; João Pinheiro-Costa Journal: Clin Ophthalmol Date: 2021-04-28