Jeremiah Easley1, James Johnson2, Daniel Regan3, Eileen Hackett1, Anthony A Romeo4, Ted Schlegel5, Cecily Broomfield2, Christian Puttlitz2, Kirk McGilvray2. 1. Preclinical Surgical Research Laboratory, Colorado State University, Fort Collins, Colorado, United States. 2. Orthopaedic Bioengineering Research Laboratory, Colorado State University, Fort Collins, Colorado, United States. 3. Flint Animal Cancer Center and Department of Microbiology, Immunology, & Pathology, Colorado State University, Fort Collins, Colorado, United States. 4. Rothman Orthopaedic Institute, New York, New York, United States. 5. Department of Orthopedics, University of Colorado School of Medicine, Aurora, Colorado, United States.
Abstract
OBJECTIVE: Rotator cuff tendon tears are the most common soft tissue injuries in the shoulder joint. Various animal models have been described for this condition, but all current translational animal models have inherent weaknesses in their ability to generate chronically degenerated rotator cuff tendons. The objective of this study was to evaluate a partial infraspinatus tendon transection model as a means of creating a chronically degenerated rotator cuff tendon in an ovine model and compare the injury characteristics of this model to those observed in human patients with severe chronic rotator cuff tendon injuries. STUDY DESIGN: The infraspinatus tendons of six sheep were partially detached followed by capping of the detached medial section of the tendon with Gore-Tex. Human tissue samples of the supraspinatus tendon were harvested from patients undergoing primary reverse shoulder arthroplasty and served as positive controls of chronic rotator cuff tendinopathy. RESULTS: Transected sheep tendons were characterized predominantly by an acute reactive and reparative pathological process as compared with the chronic degenerative changes observed in the human tendons. In contrast, the non-transected portion of the ovine tendon showed histological changes, which were more chronic and degenerative in nature when compared with the transected tendon. CONCLUSION: Overall, histological features of the non-transected portion of ovine tendon were more similar to those observed in the chronic degenerated human tendon. Georg Thieme Verlag KG Stuttgart · New York.
OBJECTIVE: Rotator cuff tendon tears are the most common soft tissue injuries in the shoulder joint. Various animal models have been described for this condition, but all current translational animal models have inherent weaknesses in their ability to generate chronically degenerated rotator cuff tendons. The objective of this study was to evaluate a partial infraspinatus tendon transection model as a means of creating a chronically degenerated rotator cuff tendon in an ovine model and compare the injury characteristics of this model to those observed in humanpatients with severe chronic rotator cuff tendon injuries. STUDY DESIGN: The infraspinatus tendons of six sheep were partially detached followed by capping of the detached medial section of the tendon with Gore-Tex. Human tissue samples of the supraspinatus tendon were harvested from patients undergoing primary reverse shoulder arthroplasty and served as positive controls of chronic rotator cuff tendinopathy. RESULTS: Transected sheep tendons were characterized predominantly by an acute reactive and reparative pathological process as compared with the chronic degenerative changes observed in the human tendons. In contrast, the non-transected portion of the ovine tendon showed histological changes, which were more chronic and degenerative in nature when compared with the transected tendon. CONCLUSION: Overall, histological features of the non-transected portion of ovine tendon were more similar to those observed in the chronic degenerated human tendon. Georg Thieme Verlag KG Stuttgart · New York.
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