Purpose: To assess which visual function measures are most strongly associated with overall retinal drusen volume in age-related macular degeneration (AMD). Methods: A total of 100 eyes (16 eyes with early AMD, 62 eyes with intermediate AMD, and 22 eyes from healthy controls) were recruited in this cross-sectional study. All subjects underwent several functional assessments: best-corrected visual acuity (BCVA), low-luminance visual acuity (LLVA), visual acuity (VA) measured with the Moorfields Acuity Chart (MAC-VA), contrast sensitivity with the Pelli-Robson test, reading speed using the International Reading Speed texts, and mesopic and dark-adapted microperimetry. Drusen volume was automatically determined based on optical coherence tomography using an approach based on convolutional neural networks. The relationship between drusen volume and visual function was assessed with linear regressions controlling for confounders. Results: Mean drusen volume and MAC-VA differed significantly among all AMD stages and controls (P < 0.001). In univariate linear regression, LLVA, MAC-VA, contrast sensitivity, and mesopic and dark-adapted microperimetry were significantly negatively associated with the overall drusen volume (all P < 0.006). After controlling for AMD stage, age, and the presence of subretinal drusenoid deposits, MAC-VA and mesopic and dark-adapted microperimetry were still significantly associated with drusen volume (P = 0.008, P = 0.023, and P = 0.022, respectively). Conclusions: Our results suggest that MAC-VA, as well as mesopic and dark-adapted microperimetry, might indicate structural changes related to drusen volume in early stages of AMD.
Purpose: To assess which visual function measures are most strongly associated with overall retinal drusen volume in age-related macular degeneration (AMD). Methods: A total of 100 eyes (16 eyes with early AMD, 62 eyes with intermediate AMD, and 22 eyes from healthy controls) were recruited in this cross-sectional study. All subjects underwent several functional assessments: best-corrected visual acuity (BCVA), low-luminance visual acuity (LLVA), visual acuity (VA) measured with the Moorfields Acuity Chart (MAC-VA), contrast sensitivity with the Pelli-Robson test, reading speed using the International Reading Speed texts, and mesopic and dark-adapted microperimetry. Drusen volume was automatically determined based on optical coherence tomography using an approach based on convolutional neural networks. The relationship between drusen volume and visual function was assessed with linear regressions controlling for confounders. Results: Mean drusen volume and MAC-VA differed significantly among all AMD stages and controls (P < 0.001). In univariate linear regression, LLVA, MAC-VA, contrast sensitivity, and mesopic and dark-adapted microperimetry were significantly negatively associated with the overall drusen volume (all P < 0.006). After controlling for AMD stage, age, and the presence of subretinal drusenoid deposits, MAC-VA and mesopic and dark-adapted microperimetry were still significantly associated with drusen volume (P = 0.008, P = 0.023, and P = 0.022, respectively). Conclusions: Our results suggest that MAC-VA, as well as mesopic and dark-adapted microperimetry, might indicate structural changes related to drusen volume in early stages of AMD.
Authors: George D Kymionis; Dimitrios G Mikropoulos; Dimitra M Portaliou; Kostantinos G Boboridis; Irini C Voudouragkaki; Nikolaos D Dragoumis; Anastasios G P Konstas Journal: Adv Ther Date: 2014-05-21 Impact factor: 3.845
Authors: Per Fagerholm; Neil S Lagali; Kimberley Merrett; W Bruce Jackson; Rejean Munger; Yuwen Liu; James W Polarek; Monica Söderqvist; May Griffith Journal: Sci Transl Med Date: 2010-08-25 Impact factor: 17.956
Authors: Wenguang Liu; Chao Deng; Christopher R McLaughlin; Per Fagerholm; Neil S Lagali; Belinda Heyne; Juan C Scaiano; Mitchell A Watsky; Yasuhiro Kato; Rejean Munger; Naoshi Shinozaki; Fengfu Li; May Griffith Journal: Biomaterials Date: 2008-12-20 Impact factor: 12.479
Authors: Monika Kozak Ljunggren; Rodolfo A Elizondo; Elle Edin; David Olsen; Kimberley Merrett; Chyan-Jang Lee; Göran Salerud; James Polarek; Per Fagerholm; May Griffith Journal: Transl Vis Sci Technol Date: 2014-04-15 Impact factor: 3.283
Authors: Eleonora M Lad; Vivienne Fang; Michel Tessier; Anna Rautanen; Javier Gayan; Sandra S Stinnett; Ulrich F O Luhmann Journal: Ophthalmol Sci Date: 2022-05-20