Xiaojia Ma1,2, Xiaoli Min3, Chang Yao4. 1. Nanjing University of Chinese Medicine, Nanjing, China. 2. Yunnan Provincial Hospital of Traditional Chinese Medicine, Kunming, China. 3. Department of Cerebrovascular Diseases, the Second Affiliated Hospital of Kunming Medical University, Kunming, China. 4. The First Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Abstract
OBJECTIVE: Granulomatous lobular mastitis (GLM) is infrequently diagnosed. This study aimed to evaluate the efficacy and safety of managements for GLM in the nonlactation period. METHODS: Publications were retrieved from PubMed, EMBASE, and the Cochrane library on September 10, 2018. We pooled and compared the outcome parameters and complete remission (CR) rates between different treatments using a meta-analysis. RESULTS: Twenty-one publications including 970 patients treated with surgical excision, steroids, abscess drainage, antibiotics, and observation were included. Surgery significantly improved CR rate compared with steroids (p = 0.0003). There was no difference in the CR rate in patients treated with surgery alone or combined with steroids (p = 0.28). Surgery showed borderline significant efficacy in the CR rate compared with antibiotics (p = 0.06) and abscess drainage (p = 0.06). No difference was observed in effectiveness between observation and surgical management in patients diagnosed with early GLM and mild symptoms. CONCLUSIONS: Although surgery was the ideal management for GLM, steroids and antibiotics might be ideal managements for GLM patients who are worried about surgical scars. Observation was an impressive alternative for patients with early GLM.
OBJECTIVE: Granulomatous lobular mastitis (GLM) is infrequently diagnosed. This study aimed to evaluate the efficacy and safety of managements for GLM in the nonlactation period. METHODS: Publications were retrieved from PubMed, EMBASE, and the Cochrane library on September 10, 2018. We pooled and compared the outcome parameters and complete remission (CR) rates between different treatments using a meta-analysis. RESULTS: Twenty-one publications including 970 patients treated with surgical excision, steroids, abscess drainage, antibiotics, and observation were included. Surgery significantly improved CR rate compared with steroids (p = 0.0003). There was no difference in the CR rate in patients treated with surgery alone or combined with steroids (p = 0.28). Surgery showed borderline significant efficacy in the CR rate compared with antibiotics (p = 0.06) and abscess drainage (p = 0.06). No difference was observed in effectiveness between observation and surgical management in patients diagnosed with early GLM and mild symptoms. CONCLUSIONS: Although surgery was the ideal management for GLM, steroids and antibiotics might be ideal managements for GLM patients who are worried about surgical scars. Observation was an impressive alternative for patients with early GLM.
Authors: Gary M K Tse; Cycles S P Poon; Kalavathy Ramachandram; Tony K F Ma; Lai-Man Pang; Bonita K B Law; Winnie C W Chu; Alice P Y Tang; Humairah S Cheung Journal: Pathology Date: 2004-06 Impact factor: 5.306
Authors: Marcia E Bouton; Lisa M Winton; Sonal G Gandhi; Lakshmi Jayaram; Prahladbhai N Patel; Patrick J O' Neill; Ian K Komenaka Journal: Int J Surg Case Rep Date: 2015-03-04