Natasha A Koloski1,2,3, Michael Jones4, Marjorie M Walker1, Gerald Holtmann2,3, Nicholas J Talley1. 1. Faculty of Health and Medicine, University of Newcastle, Callaghan, Australia. 2. Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Australia. 3. School of Medicine, University of Queensland, Brisbane, Australia. 4. Department of Psychology, Macquarie University, Ryde, Australia.
Abstract
BACKGROUND: Exercise improves symptoms of irritable bowel syndrome, but few data are available about functional dyspepsia. We compared the prevalence and frequency of different types of exercise between individuals with functional dyspepsia and general population controls. METHODS: A mailed survey was returned by 3160 people randomly obtained from the Australian electoral register. The survey included questions to identify the Rome III diagnosis for functional dyspepsia. Exercise was classified by the presence (yes or no) and the frequency (number of times) spent walking, and engaging in moderate and vigorous exercise, over the last 2 weeks based on the National Health Survey. Controls did not meet criteria for functional dyspepsia. Potential confounders included the presence of irritable bowel syndrome, smoking, body mass index, age and gender. RESULTS: A total of 14.8% (95% confidence interval (CI) 13.6%, 16.1%) subjects had functional dyspepsia. They reported significantly less walking (57% versus 63%, P = 0.04) and lower frequency of exercising, in terms of walking (P = 0.008) and engaging in moderate (P = 0.03) and vigorous activity (P = 0.02), compared with controls. The association remained significant for moderate exercise, independent of age, gender, body mass index and smoking, and excluding overlap with irritable bowel syndrome (odds ratio (OR) = 0.94 (95% CI 0.88, 0.99), P = 0.02). Postprandial distress syndrome was associated with less-vigorous exercise adjusting for confounders (OR = 0.65 (95% CI 0.42, 1.0), P = 0.05), but not epigastric pain syndrome. CONCLUSION: Functional dyspepsia is associated with lower exercise levels, but the causality still needs to be determined.
BACKGROUND: Exercise improves symptoms of irritable bowel syndrome, but few data are available about functional dyspepsia. We compared the prevalence and frequency of different types of exercise between individuals with functional dyspepsia and general population controls. METHODS: A mailed survey was returned by 3160 people randomly obtained from the Australian electoral register. The survey included questions to identify the Rome III diagnosis for functional dyspepsia. Exercise was classified by the presence (yes or no) and the frequency (number of times) spent walking, and engaging in moderate and vigorous exercise, over the last 2 weeks based on the National Health Survey. Controls did not meet criteria for functional dyspepsia. Potential confounders included the presence of irritable bowel syndrome, smoking, body mass index, age and gender. RESULTS: A total of 14.8% (95% confidence interval (CI) 13.6%, 16.1%) subjects had functional dyspepsia. They reported significantly less walking (57% versus 63%, P = 0.04) and lower frequency of exercising, in terms of walking (P = 0.008) and engaging in moderate (P = 0.03) and vigorous activity (P = 0.02), compared with controls. The association remained significant for moderate exercise, independent of age, gender, body mass index and smoking, and excluding overlap with irritable bowel syndrome (odds ratio (OR) = 0.94 (95% CI 0.88, 0.99), P = 0.02). Postprandial distress syndrome was associated with less-vigorous exercise adjusting for confounders (OR = 0.65 (95% CI 0.42, 1.0), P = 0.05), but not epigastric pain syndrome. CONCLUSION:Functional dyspepsia is associated with lower exercise levels, but the causality still needs to be determined.
Authors: Laurie Zhong; Erin R Shanahan; Ashok Raj; Natasha A Koloski; Linda Fletcher; Mark Morrison; Marjorie M Walker; Nicholas J Talley; Gerald Holtmann Journal: Gut Date: 2016-08-03 Impact factor: 23.059
Authors: Pertti Aro; Nicholas J Talley; Jukka Ronkainen; Tom Storskrubb; Michael Vieth; Sven-Erik Johansson; Elisabeth Bolling-Sternevald; Lars Agréus Journal: Gastroenterology Date: 2009-03-26 Impact factor: 22.682
Authors: Silvia S Kang; Patricio R Jeraldo; Aishe Kurti; Margret E Berg Miller; Marc D Cook; Keith Whitlock; Nigel Goldenfeld; Jeffrey A Woods; Bryan A White; Nicholas Chia; John D Fryer Journal: Mol Neurodegener Date: 2014-09-13 Impact factor: 14.195
Authors: Nicholas J Talley; Marjorie M Walker; Pertti Aro; Jukka Ronkainen; Tom Storskrubb; Laura A Hindley; W Scott Harmsen; Alan R Zinsmeister; Lars Agréus Journal: Clin Gastroenterol Hepatol Date: 2007-08-07 Impact factor: 11.382