| Literature DB >> 32224139 |
Kearsley M Dillon1, Ryan J Carrazzone1, John B Matson2, Khosrow Kashfi3.
Abstract
Nitric oxide (NO) and hydrogen sulfide (H2S) are industrial toxins or pollutants; however, both are produced endogenously and have important biological roles in most mammalian tissues. The recognition that these gasotransmitters have a role in physiological and pathophysiological processes has presented opportunities to harness their intracellular effects either through inhibition of their production; or more commonly, through inducing their levels and or delivering them by various modalities. In this review article, we have focused on an array of NO and H2S donors, their hybrids with other established classes of drugs, and the various engineered delivery platforms such a fibers, polymers, nanoparticles, hydrogels, and others. In each case, we have reviewed the rationale for their development.Entities:
Keywords: Delivery platforms; Fibers; H(2)S-releasing hybrids; Hydrogels; Hydrogen sulfide; NO-releasing compounds; Nanoparticles; Nitric oxide; Polymers
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Year: 2020 PMID： 32224139 PMCID： PMC7263970 DOI： 10.1016/j.bcp.2020.113931
Source DB: PubMed Journal: Biochem Pharmacol ISSN： 0006-2952 Impact factor: 5.858