Robson Dos Santos S Marinho1, Rodrigo L Sanz Duro1, Giulia L Santos1, James Hunter1, Maria da Aparecida Rodrigues Teles2, Rafael Brustulin3, Flavio A de Padua Milagres4, Ester C Sabino5, Ricardo S Diaz1, Shirley V Komninakis6. 1. Laboratório de Retrovirologia, Universidade Federal de São Paulo, São Paulo 04023-062, Brazil. 2. Laboratório Central de Saúde Pública Do Tocantins (LACEN/TO), Tocantins 77016-330, Brazil. 3. Secretaria de Saúde do Tocantins, Tocantins 77453-000, Brazil; Instituto de Ciências Biológicas, Universidade Federal do Tocantins, Tocantins 77001-090, Brazil; Laboratório Central de Saúde Pública Do Tocantins (LACEN/TO), Tocantins 77016-330, Brazil. 4. LIM/46, Faculdade de Medicina, Universidade de São Paulo, São Paulo 01246-903, Brazil; Secretaria de Saúde do Tocantins, Tocantins 77453-000, Brazil; Instituto de Ciências Biológicas, Universidade Federal do Tocantins, Tocantins 77001-090, Brazil; Laboratório Central de Saúde Pública Do Tocantins (LACEN/TO), Tocantins 77016-330, Brazil. 5. LIM/46, Faculdade de Medicina, Universidade de São Paulo, São Paulo 01246-903, Brazil; Instituto De Medicina Tropical, Universidade De São Paulo, São Paulo 05403-000, Brazil. 6. Laboratório de Retrovirologia, Universidade Federal de São Paulo, São Paulo 04023-062, Brazil; Faculdade de Medicina do ABC, Santo André, SP 09060-870, Brazil. Electronic address: skomninakis@yahoo.com.br.
Abstract
BACKGROUND: The co-circulation of Chikungunya (CHIKV), Dengue (DENV) and Zika (ZIKV) viruses increased the risk of outbreaks and coinfections among them. Here, we report cases of coinfection in clinical samples from state of Tocantins, Brazil. METHODS: In 2017, the Central Public Health Laboratory (LACEN) received samples of patients who consulted health units with symptoms compatible with arboviral infections. A total of 102 samples were sent to the Retrovirology Laboratory at the Federal University of São Paulo, where they were tested by RT-qPCR to confirm DENV, ZIKV and CHIKV infections and to detect coinfected patients. RESULTS: We identified with CHIKV monoinfection (52), DENV serotypes 1 (28) and serotypes 2 (22). We did not detect ZIKV. Five patients were characterized with coinfection involving CHIKV and DENV serotype 2. CONCLUSIONS: The presence of co-circulating arboviruses increases the chance of coinfection and demonstrates the importance of differential diagnosis and vector control.
BACKGROUND: The co-circulation of Chikungunya (CHIKV), Dengue (DENV) and Zika (ZIKV) viruses increased the risk of outbreaks and coinfections among them. Here, we report cases of coinfection in clinical samples from state of Tocantins, Brazil. METHODS: In 2017, the Central Public Health Laboratory (LACEN) received samples of patients who consulted health units with symptoms compatible with arboviral infections. A total of 102 samples were sent to the Retrovirology Laboratory at the Federal University of São Paulo, where they were tested by RT-qPCR to confirm DENV, ZIKV and CHIKV infections and to detect coinfected patients. RESULTS: We identified with CHIKV monoinfection (52), DENV serotypes 1 (28) and serotypes 2 (22). We did not detect ZIKV. Five patients were characterized with coinfection involving CHIKV and DENV serotype 2. CONCLUSIONS: The presence of co-circulating arboviruses increases the chance of coinfection and demonstrates the importance of differential diagnosis and vector control.
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