Luisa Agnello 1 , Giulia Bivona 1 , Elisa Parisi 2 , Giuseppe Dejan Lucido 3 , Alessandro Iacona 4 , Anna Maria Ciaccio 5 , Rosaria Vincenza Giglio 4 , Ottavio Ziino 2 , Marcello Ciaccio 1,4 Show Affiliations »
Abstract
OBJECTIVE: In this study, we investigated the roles of presepsin (PSP) and midregional proadrenomedullin (mr-proADM) in children with febrile neutropenia (FN) due to chemotherapy. METHODS: We assessed 36 FN episodes in 26 children. Patients were classified into bacteremia (B) and fever of unknown origin (FUO) groups. We evaluated PSP and mr-proADM at admission (T0), after 24/48 h (T1), and after 5 days (T2). RESULTS: PSP and mr-proADM levels were elevated at T0 and significantly decreased at T2. mr-proADM levels did not significantly differ between the B and FUO groups. PSP levels significantly differed between the B and FUO groups only at T1. Both PSP and mr-proADM levels at T0 were a predictor of length of hospital stay but not of the duration of fever. Finally, receiver operating characteristic curve analysis showed that PSP and mr-proADM had low diagnostic accuracy for blood culture positivity. CONCLUSION: PSP and mr-proADM display poor clinical usefulness for FN in oncologic children. © American Society for Clinical Pathology 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
OBJECTIVE: In this study, we investigated the roles of presepsin (PSP) and midregional proadrenomedullin (mr-proADM ) in children with febrile neutropenia (FN ) due to chemotherapy. METHODS: We assessed 36 FN episodes in 26 children . Patients were classified into bacteremia (B) and fever of unknown origin (FUO) groups. We evaluated PSP and mr-proADM at admission (T0), after 24/48 h (T1), and after 5 days (T2). RESULTS: PSP and mr-proADM levels were elevated at T0 and significantly decreased at T2. mr-proADM levels did not significantly differ between the B and FUO groups. PSP levels significantly differed between the B and FUO groups only at T1. Both PSP and mr-proADM levels at T0 were a predictor of length of hospital stay but not of the duration of fever . Finally, receiver operating characteristic curve analysis showed that PSP and mr-proADM had low diagnostic accuracy for blood culture positivity. CONCLUSION: PSP and mr-proADM display poor clinical usefulness for FN in oncologic children . © American Society for Clinical Pathology 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Entities: Chemical
Disease
Species
Keywords:
Adrenomedullin; Presepsin; fever; malignancies; mr-proADM; neutropenia; oncologic; pediatric
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Year: 2020
PMID： 32221546 DOI： 10.1093/labmed/lmaa011
Source DB: PubMed Journal: Lab Med ISSN： 0007-5027