| Literature DB >> 32216464 |
Yuanyuan Han1, Wenguang Wang1, Jie Jia, Xiaomei Sun1, Dexuan Kuang1, Pinfen Tong1, Na Li1, Caixia Lu1, Huatang Zhang2, Jiejie Dai1.
Abstract
IMPACT STATEMENT: We constructed the transcriptomic network in adipose tissue in lean, moderate obesity and severe obesity groups of tree shrew for the first time. Compared to other laboratory animal models, the tree shrew is a prospective laboratory animal that has a closer genetic association with primates than with rodents. It is widely used in biomedical researches. Enrichment analyses revealed several molecular biological processes were involved in the ribosome, lysosome, and ubiquitin-mediated proteolysis process. These results provided insights into new targets for the prevention and therapy of obesity and a novel research model for obesity.Entities:
Keywords: Weighted gene co-expression network analysis; key pathway and genes; obesity; tree shrew model
Mesh：
Year: 2020 PMID： 32216464 PMCID： PMC7427174 DOI： 10.1177/1535370220915180
Source DB: PubMed Journal: Exp Biol Med (Maywood) ISSN： 1535-3699