Fatemeh Samiee Rad1, Mahdi Ghaebi2, Simin Zarabadipour3, Arezoo Bajelan3, Fatemeh Pashazade3, Mehri Kalhor4, Amane Barikani5. 1. Department of Pathology, Metabolic Disease Research Center, Qazvin University of Medical Sciences, Qazvin, Iran. 2. General Physician, Qazvin University of Medical Sciences, Qazvin, Iran. 3. Qazvin University of Medical Sciences, Qazvin, Iran. 4. Department of Reproductive Health, Tarbiat Modarres University, Tehran, Iran. 5. Department of Epidemiology, Qazvin University of Medical Sciences, Qazvin, Iran.
Abstract
BACKGROUND & OBJECTIVE: Premalignant lesions of cervix have increased dramatically in recent years. Early diagnosis and management of abnormalities have an effective role in preventing the invasion of the disease and also in timely treatment. This study aimed to compare diagnostic methods in the detection of squamous cell abnormalities with abnormal Pap smear test. METHODS: This cross-sectional study was performed on 1000 women with abnormal Pap smears in 2007-2018. Sampling was performed with simple method. All samples were subjected to an immediate assessment of colposcopy and histopathology if suspected. The checklist included demographic information as well as symptoms, cytopathology, colposcopy and histopathology findings. Data analysis was performed using descriptive and statistical analysis (P<0.05). RESULTS: A significant relationship between histopathology and Pap smear findings was found (P=0.009), also there was a significant correlation between histopathology and colposcopy findings (P=0.001). However, there was no significant relationship between clinical symptoms and histopathology findings (p=0.8). Sensitivity , specificity , positive and negative predictive value of Pap smear were 43%, 65.9%, 75.4%, 32.2% and of colposcopy were 74.7%, 39.5%, 75%, 39.1%, and of clinical symptoms were 72.6%, 28.1%, 71.1%, 29.7%, respectively. CONCLUSION: Pap smear findings have the appropriate diagnostic accuracy in comparison with colposcopy and histopathology findings for screening and diagnosis of squamous intra-epithelial lesions. Also, there was higher sensitivity of colposcopy compared with Pap smear to detect cervical lesions. Therefore, it is advisable to use these methods simultaneously.
BACKGROUND & OBJECTIVE: Premalignant lesions of cervix have increased dramatically in recent years. Early diagnosis and management of abnormalities have an effective role in preventing the invasion of the disease and also in timely treatment. This study aimed to compare diagnostic methods in the detection of squamous cell abnormalities with abnormal Pap smear test. METHODS: This cross-sectional study was performed on 1000 women with abnormal Pap smears in 2007-2018. Sampling was performed with simple method. All samples were subjected to an immediate assessment of colposcopy and histopathology if suspected. The checklist included demographic information as well as symptoms, cytopathology, colposcopy and histopathology findings. Data analysis was performed using descriptive and statistical analysis (P<0.05). RESULTS: A significant relationship between histopathology and Pap smear findings was found (P=0.009), also there was a significant correlation between histopathology and colposcopy findings (P=0.001). However, there was no significant relationship between clinical symptoms and histopathology findings (p=0.8). Sensitivity , specificity , positive and negative predictive value of Pap smear were 43%, 65.9%, 75.4%, 32.2% and of colposcopy were 74.7%, 39.5%, 75%, 39.1%, and of clinical symptoms were 72.6%, 28.1%, 71.1%, 29.7%, respectively. CONCLUSION: Pap smear findings have the appropriate diagnostic accuracy in comparison with colposcopy and histopathology findings for screening and diagnosis of squamous intra-epithelial lesions. Also, there was higher sensitivity of colposcopy compared with Pap smear to detect cervical lesions. Therefore, it is advisable to use these methods simultaneously.
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Authors: Mert Ulaş Barut; Ahmet Kale; Umur Kuyumcuoğlu; Murat Bozkurt; Elif Ağaçayak; Server Özekinci; Talip Gül Journal: Med Sci Monit Date: 2015-12-10
Authors: Yung Taek Ouh; Ji Jeong Park; Minjoo Kang; Miseon Kim; Jae Yun Song; So Jin Shin; Seung Hyuk Shim; Heon Jong Yoo; Maria Lee; Sung Jong Lee; Whan Shin; Gun Oh Chong; Min Chul Choi; Chel Hun Choi; Kyung Jin Min Journal: J Korean Med Sci Date: 2021-06-21 Impact factor: 2.153