Patricia Dominguez Castro1, Grace Harkin2, Mary Hussey3, Brian Christopher4, Clifford Kiat2, Jun Liong Chin1, Valerie Trimble1, Deirdre McNamara3, Padraic MacMathuna5, Brian Egan6, Barbara Ryan3, David Kevans1, Mohamed Abuzakouk7, Richard Farrell8, Con Feighery9, Valerie Byrnes2, Nasir Mahmud1, Ross McManus1. 1. Trinity Translational Medicine Institute and Department of Clinical Medicine, Trinity Centre for Health Science, St James's Hospital, Dublin, Ireland. 2. Department of Clinical Medicine, University College Hospital Galway, Ireland. 3. Department of Gastroenterology, Tallaght University Hospital, Dublin, Ireland. 4. Connolly Hospital Blanchardstown, Dublin, Ireland. 5. Gastrointestinal Unit, Mater Misericordiae University Hospital, Dublin, Ireland. 6. Department of Clinical Medicine, Mayo General Hospital, Castlebar, Ireland. 7. Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates. 8. Royal College of Surgeons Ireland, Dublin, Ireland. 9. Departments of Immunology and Histopathology, St James's Hospital and Trinity College Dublin, Ireland.
Abstract
BACKGROUND: Coeliac disease (CD) is associated with an increased risk of other immune-mediated conditions. Aim: To investigate the prevalence of coexistent immune-mediated diseases in CD patients, and changes in the prevalence of autoimmune thyroidal diseases over the last 50 years. METHODS: Medical record data were collected retrospectively from 749 CD patients in Ireland. Prevalence of autoimmune diseases was compared with previously published results from general populations. Patients were divided into four groups based on the year of diagnosis to analyse changes in the prevalence of autoimmune thyroidal disease over time. RESULTS: Median age at the time of CD diagnosis was 56 years (range 18-91 years). A total of 233 (31.1%) patients had a coexistent immune-mediated condition (IMC). Autoimmune thyroidal diseases were seen in 149 (19.9%) patients, hypothyroidism in 110 (14.7%), type 1 diabetes in 27 (3.6%), psoriasis in 20 (2.7%), inflammatory bowel disease in 14 (1.9%) and rheumatoid arthritis in 12 (1.6%). All conditions were more common in CD patients than in the general population. Type 1 diabetes was diagnosed mainly before CD, whereas there was no such trend in other conditions. Autoimmune thyroidal diseases became less common in female CD patients over time. CONCLUSIONS: Prevalence of autoimmune diseases is increased in adult CD patients compared with the general population. However, concomitant autoimmune thyroidal diseases became less common over time in women.
BACKGROUND:Coeliac disease (CD) is associated with an increased risk of other immune-mediated conditions. Aim: To investigate the prevalence of coexistent immune-mediated diseases in CDpatients, and changes in the prevalence of autoimmune thyroidal diseases over the last 50 years. METHODS: Medical record data were collected retrospectively from 749 CDpatients in Ireland. Prevalence of autoimmune diseases was compared with previously published results from general populations. Patients were divided into four groups based on the year of diagnosis to analyse changes in the prevalence of autoimmune thyroidal disease over time. RESULTS: Median age at the time of CD diagnosis was 56 years (range 18-91 years). A total of 233 (31.1%) patients had a coexistent immune-mediated condition (IMC). Autoimmune thyroidal diseases were seen in 149 (19.9%) patients, hypothyroidism in 110 (14.7%), type 1 diabetes in 27 (3.6%), psoriasis in 20 (2.7%), inflammatory bowel disease in 14 (1.9%) and rheumatoid arthritis in 12 (1.6%). All conditions were more common in CDpatients than in the general population. Type 1 diabetes was diagnosed mainly before CD, whereas there was no such trend in other conditions. Autoimmune thyroidal diseases became less common in female CDpatients over time. CONCLUSIONS: Prevalence of autoimmune diseases is increased in adult CDpatients compared with the general population. However, concomitant autoimmune thyroidal diseases became less common over time in women.
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