| Literature DB >> 32212681 |
Joanna Czescik1, Yanchao Lyu1, Samuele Neuberg1, Paolo Scrimin1, Fabrizio Mancin1.
Abstract
The activity of many enzymes is regulated by associative processes. To model this mechanism, we report here that the conformation of an unstructured bimetallic Zn(II) complex can be controlled by its inclusion in the cavity of a γ-cyclodextrin. This results in the formation of a catalytic bimetallic site for the hydrolytic cleavage of the RNA model substrate HPNP, whose reactivity is 30-fold larger with respect to the unstructured complex. Competitive inhibition with 1-adamantanecarboxylate displaces the metal complex from the cyclodextrin decreasing the reactivity.Entities:
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Year: 2020 PMID： 32212681 PMCID： PMC7997383 DOI： 10.1021/jacs.9b12699
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419