COVID-19 may transmit through aerosol.

Dear Editor,

On Feb 18, the National Health Commission of the People’s Republic of China published the guidelines for the diagnosis and treatment of COVID-19 infection (trial version 6) [1]. With the awareness and understanding of the disease, the guidelines show that the droplets and close contact transmission are the main routes of transmission, and aerosol transmission is possible under the condition of long exposure to high concentrations of aerosols in a relatively closed environment [1].

Aerosols are particles formed by solid or liquid particles dispersed and suspended in the air. They contain soil particles, industrial dust particles, particulates emitted by automobiles, bacteria, microorganisms, plant spore powders, and other components. When a person, who was infected with the virus, coughs, sneezes, breathes vigorously, or speaks loudly, the virus will be excreted from the body and may dissolve with the aerosol and become the bio-aerosols. The particles in a bio-aerosol are generally 0.3 to 100 μm in diameter; however, the respirable size fraction of 1 to 10 μm is of primary concern. Bio-aerosols ranging in size from 1.0 to 5.0 μm generally remain in the air, whereas larger particles are deposited on surfaces. Droplets are droplets of saliva discharged by people sneezing or coughing, and their particle size is generally 1 to 5 mm. They spread in a space of about 1 to 2 m from the source of infection. However, the aerosol can travel hundreds of meters or more. More importantly, current researches have proven that aerosols are involved in the spread of SARS, MERS, H1N1, and some other diseases [2-5].

If COVID-19 infection cannot transmit by aerosol, it will hardly to explain some confirmed cases. On Feb 3, the Disease Control Department of Dalat Banner, Ordos City, Inner Mongolia, announced that the fourth confirmed case lived upstairs of the first confirmed case, who went up and down the building several times by passing by the door of the first confirmed case, of whom the door was often opened and there was some domestic garbage beside the door [6]. Moreover, four clinical laboratory technicians in the Department of Clinical Laboratory of Jinyintan Hospital, Wuhan, were infected with COVID-19, of whom had no contact with the confirmed cases [7]. How did they get infected? One possibility is that the patients’ blood samples are exposed to the air to form aerosols, and the viruses in the aerosols are transmitted to the four technicians. All in all, COVID-19 may transmit through aerosol directly, but it needs to be further verified by experiments. If the aerosols can spread COVID-19, prevention and control will be much more difficult.