Xiao-Dong Zhang1,2, Guang-Xue Liu3, Xiao-Yue Wang2, Xiao-Jie Huang4, Jing-Li Li1, Rui-Li Li2, Hong-Jun Li2. 1. Department of Radiology, Tianjin First Central Hospital, Tianjin 300192, People's Republic of China. 2. Department of Radiology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, People's Republic of China. 3. Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, People's Republic of China. 4. Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing 100069, People's Republic of China.
Abstract
OBJECTIVE: This study assessed the possible effect of syphilis co-infection in the brain function in young HIV patients by using voxel-wise degree centrality (DC) analysis. METHODS: Forty-four syphilis-co-infected HIV patients (HIV+/syphilis+), 45 HIV patients without syphilis history (HIV+/syphilis-) and 43 matched healthy controls (HC) underwent resting-state fMRI examinations. Laboratory tests and a battery of neuropsychological tests were performed before each MRI examination. One-way ANOVA was used to compare the differences of DC among the three groups. The correlations between MRI metrics and laboratory/neuropsychological tests in each patient's group were performed by Pearson correlation analysis. RESULTS: Compared with HIV+/syphilis-, worse performance in complex motor skills was found in HIV+/syphilis+. Compared with HC, HIV+/syphilis+ and HIV+/syphilis- groups showed attenuated DC in the right orbital frontal cortex and increased DC in the left parietal/temporal cortex. Besides, we also found increased DC in the left inferior frontal cortex and bilateral posterior cingulated cortex/precuneus in HIV+/syphilis+ compared with HC. Moreover, compared with HIV+/syphilis-, HIV+/syphilis+ displayed decreased DC in the left middle occipital cortex. Additionally, in HIV+/syphilis+ group, the mean z value of DC was correlated to the CD4+ cell counts and the learning and delayed recall score. CONCLUSION: Syphilis co-infection might be related to more brain functional reorganization in young HIV patients which could be reflected by DC value.
OBJECTIVE: This study assessed the possible effect of syphilis co-infection in the brain function in young HIV patients by using voxel-wise degree centrality (DC) analysis. METHODS: Forty-four syphilis-co-infected HIV patients (HIV+/syphilis+), 45 HIV patients without syphilis history (HIV+/syphilis-) and 43 matched healthy controls (HC) underwent resting-state fMRI examinations. Laboratory tests and a battery of neuropsychological tests were performed before each MRI examination. One-way ANOVA was used to compare the differences of DC among the three groups. The correlations between MRI metrics and laboratory/neuropsychological tests in each patient's group were performed by Pearson correlation analysis. RESULTS: Compared with HIV+/syphilis-, worse performance in complex motor skills was found in HIV+/syphilis+. Compared with HC, HIV+/syphilis+ and HIV+/syphilis- groups showed attenuated DC in the right orbital frontal cortex and increased DC in the left parietal/temporal cortex. Besides, we also found increased DC in the left inferior frontal cortex and bilateral posterior cingulated cortex/precuneus in HIV+/syphilis+ compared with HC. Moreover, compared with HIV+/syphilis-, HIV+/syphilis+ displayed decreased DC in the left middle occipital cortex. Additionally, in HIV+/syphilis+ group, the mean z value of DC was correlated to the CD4+ cell counts and the learning and delayed recall score. CONCLUSION: Syphilis co-infection might be related to more brain functional reorganization in young HIV patients which could be reflected by DC value.
Authors: Randy L Buckner; Jorge Sepulcre; Tanveer Talukdar; Fenna M Krienen; Hesheng Liu; Trey Hedden; Jessica R Andrews-Hanna; Reisa A Sperling; Keith A Johnson Journal: J Neurosci Date: 2009-02-11 Impact factor: 6.167
Authors: S A Lukehart; E W Hook; S A Baker-Zander; A C Collier; C W Critchlow; H H Handsfield Journal: Ann Intern Med Date: 1988-12-01 Impact factor: 25.391
Authors: Nishiena S Gandhi; Richard L Skolasky; Katherine B Peters; Richard T Moxley; Jason Creighton; Heidi Vornbrock Roosa; Ola A Selnes; Justin McArthur; Ned Sacktor Journal: J Neurovirol Date: 2011-03-25 Impact factor: 2.643
Authors: Jewell B Thomas; Matthew R Brier; Mario Ortega; Tammie L Benzinger; Beau M Ances Journal: Neurobiol Aging Date: 2014-06-21 Impact factor: 4.673
Authors: Stéfan Du Plessis; Matthijs Vink; John A Joska; Eleni Koutsilieri; Dan J Stein; Robin Emsley Journal: AIDS Date: 2014-03-27 Impact factor: 4.177