Na-Young Shin1, Jinwoo Hong2, Jun Yong Choi3, Seung-Koo Lee4, Soo Mee Lim5, Uicheul Yoon6. 1. Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul, Korea. 2. Department of Biomedical Engineering, College of Health and Medical Science, Catholic University of Daegu, Hayang-Ro 13-13, Hayang-Eup, Gyeongsan-si, Gyeongbuk, Republic of Korea, 38430. 3. Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine, Seoul, Korea. 4. Department of Radiology, Yonsei University College of Medicine, Seoul, Korea. 5. Department of Radiology, Ewha Womans University, School of Medicine, Seoul, Korea. 6. Department of Biomedical Engineering, College of Health and Medical Science, Catholic University of Daegu, Hayang-Ro 13-13, Hayang-Eup, Gyeongsan-si, Gyeongbuk, Republic of Korea, 38430. yoonuc@cu.ac.kr.
Abstract
OBJECTIVES: To identify brain cortical regions relevant to HIV-associated neurocognitive disorder (HAND) in HIV patients. METHODS: HIV patients with HAND (n = 10), those with intact cognition (HIV-IC; n = 12), and age-matched, seronegative controls (n = 11) were recruited. All participants were male and underwent 3-dimensional T1-weighted imaging. Both vertex-wise and region of interest (ROI) analyses were performed to analyse cortical thickness. RESULTS: Compared to controls, both HIV-IC and HAND showed decreased cortical thickness mainly in the bilateral primary sensorimotor areas, extending to the prefrontal and parietal cortices. When directly comparing HIV-IC and HAND, HAND showed cortical thinning in the left retrosplenial cortex, left dorsolateral prefrontal cortex, left inferior parietal lobule, bilateral superior medial prefrontal cortices, right temporoparietal junction and left hippocampus, and cortical thickening in the left middle occipital cortex. Left retrosplenial cortical thinning showed significant correlation with slower information processing, declined verbal memory and executive function, and impaired fine motor skills. CONCLUSIONS: This study supports previous research suggesting the selective vulnerability of the primary sensorimotor cortices and associations between cortical thinning in the prefrontal and parietal cortices and cognitive impairment in HIV-infected patients. Furthermore, for the first time, we propose retrosplenial cortical thinning as a possible major contributor to HIV-associated cognitive impairment. KEY POINTS: • Primary sensorimotor and supplementary motor cortices were selectively vulnerable to HIV infection • Prefrontal and parietal cortical thinning was associated with HIV-associated cognitive impairment • Retrosplenial cortical thinning might be a major contributor to HIV-associated cognitive impairment.
OBJECTIVES: To identify brain cortical regions relevant to HIV-associated neurocognitive disorder (HAND) in HIV patients. METHODS: HIV patients with HAND (n = 10), those with intact cognition (HIV-IC; n = 12), and age-matched, seronegative controls (n = 11) were recruited. All participants were male and underwent 3-dimensional T1-weighted imaging. Both vertex-wise and region of interest (ROI) analyses were performed to analyse cortical thickness. RESULTS: Compared to controls, both HIV-IC and HAND showed decreased cortical thickness mainly in the bilateral primary sensorimotor areas, extending to the prefrontal and parietal cortices. When directly comparing HIV-IC and HAND, HAND showed cortical thinning in the left retrosplenial cortex, left dorsolateral prefrontal cortex, left inferior parietal lobule, bilateral superior medial prefrontal cortices, right temporoparietal junction and left hippocampus, and cortical thickening in the left middle occipital cortex. Left retrosplenial cortical thinning showed significant correlation with slower information processing, declined verbal memory and executive function, and impaired fine motor skills. CONCLUSIONS: This study supports previous research suggesting the selective vulnerability of the primary sensorimotor cortices and associations between cortical thinning in the prefrontal and parietal cortices and cognitive impairment in HIV-infectedpatients. Furthermore, for the first time, we propose retrosplenial cortical thinning as a possible major contributor to HIV-associated cognitive impairment. KEY POINTS: • Primary sensorimotor and supplementary motor cortices were selectively vulnerable to HIV infection • Prefrontal and parietal cortical thinning was associated with HIV-associated cognitive impairment • Retrosplenial cortical thinning might be a major contributor to HIV-associated cognitive impairment.
Entities:
Keywords:
Atrophy; Grey matter; HIV; Magnetic resonance imaging; Neurocognitive disorders
Authors: Hea Won Ann; Suhnyoung Jun; Na-Young Shin; Sanghoon Han; Jin Young Ahn; Mi Young Ahn; Yong Duk Jeon; In Young Jung; Moo Hyun Kim; Woo Yong Jeong; Nam Su Ku; June Myung Kim; Davey M Smith; Jun Yong Choi Journal: PLoS One Date: 2016-04-22 Impact factor: 3.240
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