Literature DB >> 32206695

In vitro anti-HIV-1 activity of ethyl gallate.

C Muddu Krishna1,2, J N Kolla2, S Asha1, T Sravan Kumar Reddy2.   

Abstract

In recent years, the exploration for potential inhibitors of HIV has been increased due to the development of drug resistant HIV strains in infected people undergoing antiretroviral agents treatment. In this report, we studied the anti-HIV properties of ethyl gallate (EG) against a panel of HIV-1 strains in in vitro conditions. Different clinical isolates and laboratory strains of HIV-1 were tested for their sensitivity with EG. We found that EG exhibited non-toxic nature over a wide range of cell lines from different tissue origin. Serum proteins have little to no impact on the antiviral activity of EG. In the present study, EG was found to be a promising anti-HIV agent. © Indian Virological Society 2019.

Entities:  

Keywords:  Anti-HIV; Cytotoxicity; Ethyl gallate; HIV-1 clinical isolates; Serum shift

Year:  2019        PMID： 32206695      PMCID： PMC7085494          DOI： 10.1007/s13337-019-00562-1

Source DB:  PubMed          Journal:  Virusdisease        ISSN： 2347-3584


  21 in total

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