OBJECTIVES: Chronic obstructive pulmonary disease (COPD) increases the risk of lung cancer. The relationships between COPD and Asthma COPD Overlap (ACO), and between the histopathological types of lung cancer and driver mutations remain unclear and need further study. The aim of this retrospective study was to examine the relationships between the histopathological type, frequency of epidermal growth factor receptor (EGFR) driver mutations, and anaplastic lymphoma receptor tyrosine kinase (ALK) rearrangements in the lung cancers of patients with COPD and ACO. MATERIALS AND METHODS: Patients with pure COPD (n=198) or ACO (n=318) who were admitted to our hospital were reviewed retrospectively. RESULTS: Lung cancers were identified in 43 (21.7%) patients with pure COPD and 54 (17.0%) patients with ACO. The following lung cancers types were observed: patients with pure COPD had 19 (44.2%) adenocarcinomas, 13 (30.2%) squamous cell lung carcinomas (SCC), 8 (18.6%) small cell lung carcinomas (SCLC); patients with ACO had 23 (42.6%) adenocarcinomas, 23 (42.6%) SCC, 2 (3.70%) SCLC. SCLC was significantly more prevalent in patients with pure COPD (p<0.05) than in those with ACO. Differences between the numbers of other histological types of lung cancer and the numbers of driver mutations in the 2 groups of patients were not significant. CONCLUSION: The differences in the rate of lung cancer and prevalence of EGFR driver mutations between the patients with pure COPD and those with ACO were not significant.
OBJECTIVES:Chronic obstructive pulmonary disease (COPD) increases the risk of lung cancer. The relationships between COPD and Asthma COPD Overlap (ACO), and between the histopathological types of lung cancer and driver mutations remain unclear and need further study. The aim of this retrospective study was to examine the relationships between the histopathological type, frequency of epidermal growth factor receptor (EGFR) driver mutations, and anaplastic lymphoma receptor tyrosine kinase (ALK) rearrangements in the lung cancers of patients with COPD and ACO. MATERIALS AND METHODS:Patients with pure COPD (n=198) or ACO (n=318) who were admitted to our hospital were reviewed retrospectively. RESULTS:Lung cancers were identified in 43 (21.7%) patients with pure COPD and 54 (17.0%) patients with ACO. The following lung cancers types were observed: patients with pure COPD had 19 (44.2%) adenocarcinomas, 13 (30.2%) squamous cell lung carcinomas (SCC), 8 (18.6%) small cell lung carcinomas (SCLC); patients with ACO had 23 (42.6%) adenocarcinomas, 23 (42.6%) SCC, 2 (3.70%) SCLC. SCLC was significantly more prevalent in patients with pure COPD (p<0.05) than in those with ACO. Differences between the numbers of other histological types of lung cancer and the numbers of driver mutations in the 2 groups of patients were not significant. CONCLUSION: The differences in the rate of lung cancer and prevalence of EGFR driver mutations between the patients with pure COPD and those with ACO were not significant.
Authors: Borja G Cosio; Joan B Soriano; Jose Luis López-Campos; Myriam Calle-Rubio; Juan José Soler-Cataluna; Juan P de-Torres; Jose M Marín; Cristina Martínez-Gonzalez; Pilar de Lucas; Isabel Mir; Germán Peces-Barba; Nuria Feu-Collado; Ingrid Solanes; Inmaculada Alfageme; Ciro Casanova Journal: Chest Date: 2016-01-06 Impact factor: 9.410
Authors: Albert Rosenberger; Heike Bickeböller; Valerie McCormack; Darren R Brenner; Eric J Duell; Anne Tjønneland; Soren Friis; Joshua E Muscat; Ping Yang; H-Erich Wichmann; Joachim Heinrich; Neonila Szeszenia-Dabrowska; Jolanta Lissowska; David Zaridze; Peter Rudnai; Eleonora Fabianova; Vladimir Janout; Vladimir Bencko; Paul Brennan; Dana Mates; Ann G Schwartz; Michele L Cote; Zuo-Feng Zhang; Hal Morgenstern; Sam S Oh; John K Field; Olaide Raji; John R McLaughlin; John Wiencke; Loic LeMarchand; Monica Neri; Stefano Bonassi; Angeline S Andrew; Qing Lan; Wei Hu; Irene Orlow; Bernard J Park; Paolo Boffetta; Rayjean J Hung Journal: Carcinogenesis Date: 2011-12-22 Impact factor: 4.944
Authors: Rachel Denholm; Joachim Schüz; Kurt Straif; Isabelle Stücker; Karl-Heinz Jöckel; Darren R Brenner; Sara De Matteis; Paolo Boffetta; Florence Guida; Irene Brüske; Heinz-Erich Wichmann; Maria Teresa Landi; Neil Caporaso; Jack Siemiatycki; Wolfgang Ahrens; Hermann Pohlabeln; David Zaridze; John K Field; John McLaughlin; Paul Demers; Neonila Szeszenia-Dabrowska; Jolanta Lissowska; Peter Rudnai; Eleonora Fabianova; Rodica Stanescu Dumitru; Vladimir Bencko; Lenka Foretova; Vladimir Janout; Benjamin Kendzia; Susan Peters; Thomas Behrens; Roel Vermeulen; Thomas Brüning; Hans Kromhout; Ann C Olsson Journal: Am J Respir Crit Care Med Date: 2014-09-01 Impact factor: 21.405
Authors: Joan B Soriano; Kourtney J Davis; Bobbie Coleman; George Visick; David Mannino; Neil B Pride Journal: Chest Date: 2003-08 Impact factor: 9.410