Literature DB >> 32200795

Splice or Die: When MYC Is Driving, Transcription Needs NUAK1 to Avoid Fatal Pileups.

Robert P Fisher1.   

Abstract

In this issue of Molecular Cell, Cossa et al. (2020) uncover the basis for a dependency of tumor cells with deregulated MYC on the kinase NUAK1, which acts through PP1 and PNUTS to ensure that splicing keeps up with MYC-driven transcription.
Copyright © 2020 Elsevier Inc. All rights reserved.

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Year:  2020        PMID： 32200795      PMCID： PMC7910809          DOI： 10.1016/j.molcel.2020.02.025

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  10 in total

1.  PP1/PP2A phosphatases are required for the second step of Pre-mRNA splicing and target specific snRNP proteins.

Authors:  Yongsheng Shi; Bharat Reddy; James L Manley
Journal:  Mol Cell       Date:  2006-09-15       Impact factor: 17.970

2.  New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion.

Authors:  Anna Zagórska; Maria Deak; David G Campbell; Sourav Banerjee; Mariko Hirano; Shinichi Aizawa; Alan R Prescott; Dario R Alessi
Journal:  Sci Signal       Date:  2010-03-30       Impact factor: 8.192

3.  Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription.

Authors:  Giacomo Cossa; Isabelle Roeschert; Florian Prinz; Apoorva Baluapuri; Raphael Silveira Vidal; Christina Schülein-Völk; Yun-Chien Chang; Carsten Patrick Ade; Guido Mastrobuoni; Cyrille Girard; Lars Wortmann; Susanne Walz; Reinhard Lührmann; Stefan Kempa; Bernhard Kuster; Elmar Wolf; Dominik Mumberg; Martin Eilers
Journal:  Mol Cell       Date:  2020-01-31       Impact factor: 17.970

4.  Deregulated MYC expression induces dependence upon AMPK-related kinase 5.

Authors:  Lidan Liu; Jannes Ulbrich; Judith Müller; Torsten Wüstefeld; Lukas Aeberhard; Theresia R Kress; Nathiya Muthalagu; Lukas Rycak; Ramona Rudalska; Roland Moll; Stefan Kempa; Lars Zender; Martin Eilers; Daniel J Murphy
Journal:  Nature       Date:  2012-03-28       Impact factor: 49.962

5.  mRNA decapping factors and the exonuclease Xrn2 function in widespread premature termination of RNA polymerase II transcription.

Authors:  Kris Brannan; Hyunmin Kim; Benjamin Erickson; Kira Glover-Cutter; Soojin Kim; Nova Fong; Lauren Kiemele; Kirk Hansen; Richard Davis; Jens Lykke-Andersen; David L Bentley
Journal:  Mol Cell       Date:  2012-04-05       Impact factor: 17.970

6.  Control of RNA Pol II Speed by PNUTS-PP1 and Spt5 Dephosphorylation Facilitates Termination by a "Sitting Duck Torpedo" Mechanism.

Authors:  Michael A Cortazar; Ryan M Sheridan; Benjamin Erickson; Nova Fong; Kira Glover-Cutter; Kristopher Brannan; David L Bentley
Journal:  Mol Cell       Date:  2019-10-30       Impact factor: 17.970

7.  MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation.

Authors:  Apoorva Baluapuri; Julia Hofstetter; Nevenka Dudvarski Stankovic; Theresa Endres; Pranjali Bhandare; Seychelle Monique Vos; Bikash Adhikari; Jessica Denise Schwarz; Ashwin Narain; Markus Vogt; Shuang-Yan Wang; Robert Düster; Lisa Anna Jung; Jens Thorsten Vanselow; Armin Wiegering; Matthias Geyer; Hans Michael Maric; Peter Gallant; Susanne Walz; Andreas Schlosser; Patrick Cramer; Martin Eilers; Elmar Wolf
Journal:  Mol Cell       Date:  2019-03-27       Impact factor: 17.970

Review 8.  Transcriptional termination in mammals: Stopping the RNA polymerase II juggernaut.

Authors:  Nick J Proudfoot
Journal:  Science       Date:  2016-06-10       Impact factor: 47.728

9.  The spliceosome is a therapeutic vulnerability in MYC-driven cancer.

Authors:  Tiffany Y-T Hsu; Lukas M Simon; Nicholas J Neill; Richard Marcotte; Azin Sayad; Christopher S Bland; Gloria V Echeverria; Tingting Sun; Sarah J Kurley; Siddhartha Tyagi; Kristen L Karlin; Rocio Dominguez-Vidaña; Jessica D Hartman; Alexander Renwick; Kathleen Scorsone; Ronald J Bernardi; Samuel O Skinner; Antrix Jain; Mayra Orellana; Chandraiah Lagisetti; Ido Golding; Sung Y Jung; Joel R Neilson; Xiang H-F Zhang; Thomas A Cooper; Thomas R Webb; Benjamin G Neel; Chad A Shaw; Thomas F Westbrook
Journal:  Nature       Date:  2015-09-02       Impact factor: 49.962

10.  A Cdk9-PP1 switch regulates the elongation-termination transition of RNA polymerase II.

Authors:  Pabitra K Parua; Gregory T Booth; Miriam Sansó; Bradley Benjamin; Jason C Tanny; John T Lis; Robert P Fisher
Journal:  Nature       Date:  2018-06-13       Impact factor: 49.962
  10 in total

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