Literature DB >> 32200132

Shaping humoral immunity to vaccines through antigen-displaying nanoparticles.

Darrell J Irvine1, Benjamin J Read2.   

Abstract

Strategies to qualitatively and quantitatively enhance the humoral response to immunizations with protein and polysaccharide antigens are of broad interest for development of new and more effective vaccines. A strategy of increasing importance is the formulation of antigens into a particulate format, mimicking the physical form of viruses. The potential benefits of enhanced B cell receptor engagement by nanoparticles have been long been appreciated, but recent studies are defining additional important factors governing how nanoparticle immunogens interact with the immune system in the context of lymphoid organs. This review will discuss findings about how nanoparticles enhance humoral immunity in vivo and factors governing the fate of nanoparticle immunogens in lymph nodes.
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

Entities:  

Year:  2020        PMID： 32200132      PMCID： PMC7501207          DOI： 10.1016/j.coi.2020.01.007

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  48 in total

1.  The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node.

Authors:  Michael Sixt; Nobuo Kanazawa; Manuel Selg; Thomas Samson; Gunnel Roos; Dieter P Reinhardt; Reinhard Pabst; Manfred B Lutz; Lydia Sorokin
Journal:  Immunity       Date:  2005-01       Impact factor: 31.745

Review 2.  Bioengineering bacterial outer membrane vesicles as vaccine platform.

Authors:  Matthias J H Gerritzen; Dirk E Martens; René H Wijffels; Leo van der Pol; Michiel Stork
Journal:  Biotechnol Adv       Date:  2017-05-15       Impact factor: 14.227

3.  Nanoparticle-based B-cell targeting vaccines: Tailoring of humoral immune responses by functionalization with different TLR-ligands.

Authors:  Claudia Zilker; Diana Kozlova; Viktoriya Sokolova; Huimin Yan; Matthias Epple; Klaus Überla; Vladimir Temchura
Journal:  Nanomedicine       Date:  2016-09-02       Impact factor: 5.307

4.  Macrophage Death following Influenza Vaccination Initiates the Inflammatory Response that Promotes Dendritic Cell Function in the Draining Lymph Node.

Authors:  Nikolaos Chatziandreou; Yagmur Farsakoglu; Miguel Palomino-Segura; Rocco D'Antuono; Diego Ulisse Pizzagalli; Federica Sallusto; Veronika Lukacs-Kornek; Mariagrazia Uguccioni; Davide Corti; Shannon J Turley; Antonio Lanzavecchia; Michael C Carroll; Santiago F Gonzalez
Journal:  Cell Rep       Date:  2017-03-07       Impact factor: 9.423

5.  Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes.

Authors:  Santiago F Gonzalez; Veronika Lukacs-Kornek; Michael P Kuligowski; Lisa A Pitcher; Søren E Degn; Young-A Kim; Mary J Cloninger; Luisa Martinez-Pomares; Siamon Gordon; Shannon J Turley; Michael C Carroll
Journal:  Nat Immunol       Date:  2010-03-21       Impact factor: 25.606

6.  High-Density Array of Well-Ordered HIV-1 Spikes on Synthetic Liposomal Nanoparticles Efficiently Activate B Cells.

Authors:  Jidnyasa Ingale; Armando Stano; Javier Guenaga; Shailendra Kumar Sharma; David Nemazee; Michael B Zwick; Richard T Wyatt
Journal:  Cell Rep       Date:  2016-05-19       Impact factor: 9.423

7.  Enhancing Humoral Responses Against HIV Envelope Trimers via Nanoparticle Delivery with Stabilized Synthetic Liposomes.

Authors:  Talar Tokatlian; Daniel W Kulp; Andrew A Mutafyan; Christopher A Jones; Sergey Menis; Erik Georgeson; Mike Kubitz; Michael H Zhang; Mariane B Melo; Murillo Silva; Dong Soo Yun; William R Schief; Darrell J Irvine
Journal:  Sci Rep       Date:  2018-11-08       Impact factor: 4.379

8.  Lymph node conduits transport virions for rapid T cell activation.

Authors:  Glennys V Reynoso; Andrea S Weisberg; John P Shannon; Daniel T McManus; Lucas Shores; Jeffrey L Americo; Radu V Stan; Jonathan W Yewdell; Heather D Hickman
Journal:  Nat Immunol       Date:  2019-03-18       Impact factor: 25.606

9.  Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle.

Authors:  Philip J M Brouwer; Aleksandar Antanasijevic; Zachary Berndsen; Anila Yasmeen; Brooke Fiala; Tom P L Bijl; Ilja Bontjer; Jacob B Bale; William Sheffler; Joel D Allen; Anna Schorcht; Judith A Burger; Miguel Camacho; Daniel Ellis; Christopher A Cottrell; Anna-Janina Behrens; Marco Catalano; Iván Del Moral-Sánchez; Thomas J Ketas; Celia LaBranche; Marit J van Gils; Kwinten Sliepen; Lance J Stewart; Max Crispin; David C Montefiori; David Baker; John P Moore; Per Johan Klasse; Andrew B Ward; Neil P King; Rogier W Sanders
Journal:  Nat Commun       Date:  2019-09-19       Impact factor: 14.919

10.  An integrin/MFG-E8 shuttle loads HIV-1 viral-like particles onto follicular dendritic cells in mouse lymph node.

Authors:  Chung Park; John H Kehrl
Journal:  Elife       Date:  2019-12-06       Impact factor: 8.140
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  27 in total

1.  Absolute Quantification of Nanoparticle Interactions with Individual Human B Cells by Single Cell Mass Spectrometry.

Authors:  Nathan D Donahue; Vinit Sheth; Alex N Frickenstein; Alyssa Holden; Sandy Kanapilly; Chady Stephan; Stefan Wilhelm
Journal:  Nano Lett       Date:  2022-05-05       Impact factor: 12.262

2.  A mRNA Vaccine Encoding for a RBD 60-mer Nanoparticle Elicits Neutralizing Antibodies and Protective Immunity Against the SARS-CoV-2 Delta Variant in Transgenic K18-hACE2 Mice.

Authors:  Pascal Brandys; Xavier Montagutelli; Irena Merenkova; Güliz T Barut; Volker Thiel; Nicholas J Schork; Bettina Trüeb; Laurine Conquet; Aihua Deng; Aleksandar Antanasijevic; Hyun-Ku Lee; Martine Valière; Anoop Sindhu; Gita Singh; Jens Herold
Journal:  Front Immunol       Date:  2022-07-06       Impact factor: 8.786

3.  A Powassan virus domain III nanoparticle immunogen elicits neutralizing and protective antibodies in mice.

Authors:  Ryan J Malonis; George I Georgiev; Denise Haslwanter; Laura A VanBlargan; Georgia Fallon; Olivia Vergnolle; Sean M Cahill; Richard Harris; David Cowburn; Kartik Chandran; Michael S Diamond; Jonathan R Lai
Journal:  PLoS Pathog       Date:  2022-06-09       Impact factor: 7.464

4.  Resurfaced ZIKV EDIII nanoparticle immunogens elicit neutralizing and protective responses in vivo.

Authors:  George I Georgiev; Ryan J Malonis; Ariel S Wirchnianski; Alex W Wessel; Helen S Jung; Sean M Cahill; Elisabeth K Nyakatura; Olivia Vergnolle; Kimberly A Dowd; David Cowburn; Theodore C Pierson; Michael S Diamond; Jonathan R Lai
Journal:  Cell Chem Biol       Date:  2022-02-28       Impact factor: 9.039

Review 5.  Novel approaches for vaccine development.

Authors:  Makda S Gebre; Luis A Brito; Lisa H Tostanoski; Darin K Edwards; Andrea Carfi; Dan H Barouch
Journal:  Cell       Date:  2021-03-18       Impact factor: 41.582

Review 6.  Protein-based antigen presentation platforms for nanoparticle vaccines.

Authors:  Brian Nguyen; Niraj H Tolia
Journal:  NPJ Vaccines       Date:  2021-05-13       Impact factor: 7.344

7.  Red Blood Cell Hitchhiking: A Novel Approach for Vascular Delivery of Nanocarriers.

Authors:  Jacob S Brenner; Samir Mitragotri; Vladimir R Muzykantov
Journal:  Annu Rev Biomed Eng       Date:  2021-03-31       Impact factor: 11.324

Review 8.  Emerging skin-targeted drug delivery strategies to engineer immunity: A focus on infectious diseases.

Authors:  Emrullah Korkmaz; Stephen C Balmert; Cara Donahue Carey; Geza Erdos; Louis D Falo
Journal:  Expert Opin Drug Deliv       Date:  2020-10-06       Impact factor: 8.129

9.  Aggregation by peptide conjugation rescues poor immunogenicity of the HA stem.

Authors:  Wenbo Jiang; Emily H Pilkington; Hannah G Kelly; Hyon-Xhi Tan; Jennifer A Juno; Adam K Wheatley; Stephen J Kent
Journal:  PLoS One       Date:  2020-11-02       Impact factor: 3.240

10.  Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2.

Authors:  Alexandra C Walls; Brooke Fiala; Alexandra Schäfer; Samuel Wrenn; Minh N Pham; Michael Murphy; Longping V Tse; Laila Shehata; Megan A O'Connor; Chengbo Chen; Mary Jane Navarro; Marcos C Miranda; Deleah Pettie; Rashmi Ravichandran; John C Kraft; Cassandra Ogohara; Anne Palser; Sara Chalk; E-Chiang Lee; Elizabeth Kepl; Cameron M Chow; Claire Sydeman; Edgar A Hodge; Brieann Brown; Jim T Fuller; Kenneth H Dinnon; Lisa E Gralinski; Sarah R Leist; Kendra L Gully; Thomas B Lewis; Miklos Guttman; Helen Y Chu; Kelly K Lee; Deborah H Fuller; Ralph S Baric; Paul Kellam; Lauren Carter; Marion Pepper; Timothy P Sheahan; David Veesler; Neil P King
Journal:  bioRxiv       Date:  2020-08-12
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