| Literature DB >> 32193362 |
Zhangsen Zhou1, Mauricio Torres1, Haibo Sha2, Christopher J Halbrook1, Françoise Van den Bergh1, Rachel B Reinert3, Tatsuya Yamada4, Siwen Wang1, Yingying Luo1, Allen H Hunter5, Chunqing Wang6, Thomas H Sanderson1,7, Meilian Liu6, Aaron Taylor8, Hiromi Sesaki4, Costas A Lyssiotis1,9,10, Jun Wu1,11, Sander Kersten12, Daniel A Beard1, Ling Qi13,3.
Abstract
The endoplasmic reticulum (ER) engages mitochondria at specialized ER domains known as mitochondria-associated membranes (MAMs). Here, we used three-dimensional high-resolution imaging to investigate the formation of pleomorphic "megamitochondria" with altered MAMs in brown adipocytes lacking the Sel1L-Hrd1 protein complex of ER-associated protein degradation (ERAD). Mice with ERAD deficiency in brown adipocytes were cold sensitive and exhibited mitochondrial dysfunction. ERAD deficiency affected ER-mitochondria contacts and mitochondrial dynamics, at least in part, by regulating the turnover of the MAM protein, sigma receptor 1 (SigmaR1). Thus, our study provides molecular insights into ER-mitochondrial cross-talk and expands our understanding of the physiological importance of Sel1L-Hrd1 ERAD.Entities:
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Year: 2020 PMID： 32193362 PMCID： PMC7409365 DOI： 10.1126/science.aay2494
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728