| Literature DB >> 32190787 |
Matthew M Crane1, Mitsuhiro Tsuchiya1, Ben W Blue1, Jared D Almazan1, Kenneth L Chen1,2,3, Siobhan R Duffy1, Alexandra Golubeva1, Annaiz M Grimm1, Alison M Guard1, Shauna A Hill1, Ellen Huynh1, Ryan M Kelly1, Michael Kiflezghi1, Hyunsung D Kim1, Mitchell Lee1, Ting-I Lee1, Jiayi Li1, Bao M G Nguyen1, Riley M Whalen1, Feng Y Yeh1, Mark McCormick4, Brian K Kennedy5, Joe R Delaney6, Matt Kaeberlein1,2.
Abstract
An increase in cell size with age is a characteristic feature of replicative aging in budding yeast. Deletion of the gene encoding Whi5 results in shortened duration of G1 and reduced cell size, and has been previously suggested to increase replicative lifespan. Upon careful analysis of multiple independently derived haploid and homozygous diploid whi5Δ mutants, we find no effect on lifespan, but we do confirm the reduction in cell size. We suggest that instead of antagonizing lifespan, the elongated G1 phase of the cell cycle during aging may actually play an important role in allowing aged cells time to repair accumulating DNA damage.Entities:
Year: 2019 PMID： 32190787 PMCID： PMC7080187 DOI： 10.1016/j.tma.2019.10.002
Source DB: PubMed Journal: Transl Med Aging ISSN： 2468-5011