PURPOSE OF REVIEW: A vasculitic pattern of injury seen on brain biopsy can be attributed to a multitude of primary or secondary disorders, leading to diagnostic challenges for clinicians. RECENT FINDINGS: This report describes the clinical presentation and histopathologic findings in 2 patients who initially received a diagnosis of primary CNS vasculitis, but did not show long-term response to treatment. In both cases, a second biopsy was performed, and the final diagnosis was primary CNS lymphoma (PCNSL). SUMMARY: Analyzing diagnostically challenging cases can increase recognition of PCNSL and improve outcomes in this rare condition.
PURPOSE OF REVIEW: A vasculitic pattern of injury seen on brain biopsy can be attributed to a multitude of primary or secondary disorders, leading to diagnostic challenges for clinicians. RECENT FINDINGS: This report describes the clinical presentation and histopathologic findings in 2 patients who initially received a diagnosis of primary CNS vasculitis, but did not show long-term response to treatment. In both cases, a second biopsy was performed, and the final diagnosis was primary CNS lymphoma (PCNSL). SUMMARY: Analyzing diagnostically challenging cases can increase recognition of PCNSL and improve outcomes in this rare condition.
Authors: Martina Deckert; Anna Brunn; Manuel Montesinos-Rongen; Maria Rosa Terreni; Maurilio Ponzoni Journal: Hematol Oncol Date: 2013-08-16 Impact factor: 5.271
Authors: N F Belachew; M Diebold; P C Reinacher; M Prinz; H Urbach; D Erny; C A Taschner Journal: Clin Neuroradiol Date: 2022-07-26 Impact factor: 3.156