Eva Havers-Borgersen1, Jawad H Butt2, Lauge Østergaard2, Henning Bundgaard2, Morten Smerup3, Niels Eske Bruun4,5,6, Gunnar H Gislason7, Christian Torp-Pedersen8, Lars Køber2, Emil L Fosbøl2. 1. Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark. evaborgersen@gmail.com. 2. Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark. 3. Department of Cardiothoracic Surgery, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. 4. Department of Cardiology, Zealand University Hospital, Roskilde, Denmark. 5. Clinical Institute, Copenhagen University, Copenhagen, Denmark. 6. Clinical Institute, Aalborg University, Aalborg, Denmark. 7. Department of Cardiology, Herlev and Gentofte University Hospital, Hellerup, Denmark. 8. Department of Cardiology, Nordsjællands Hospital, Hillerød, Denmark.
Abstract
OBJECTIVE: Infective endocarditis (IE) may require heart valve surgery. It is well known that heart valve surgery itself and previous IE predispose to IE. However, data are sparse on whether the risk of IE is different among patients undergoing valve surgery due to IE and other causes (i.e. recurrent vs. first-time IE). METHODS: Using Danish nationwide registries, patients undergoing left-sided heart valve surgery in the course of an IE hospitalization (1996-2017) were identified and matched with controls undergoing left-sided heart valve surgery due to another cause than IE in a 1:1 ratio. Patients were stratified according to type of surgical valve intervention and affected valve. The comparative risk of recurrent vs. first-time IE was assessed by cumulative incidence curves and multivariable Cox regression analyses. RESULTS: The study population comprised 971 patients with a first-time admission for IE requiring heart valve surgery matched with 971 controls undergoing heart valve surgery due to other causes than IE. The risk of recurrent IE was significantly higher than the risk of first-time IE following heart valve surgery (5.5% and 3.0% by 10 years, hazard ratio (HR) 1.66, 95% confidence interval (CI) 1.02-2.70). The risk of IE recurrence was not significantly different comparing valve replacement and valve repair (5.5% and 5.3%, respectively, HR 1.60, 95% CI 0.71-3.60). Yet, the risk of IE recurrence was significantly higher among patients with biological versus mechanical prostheses (6.3% and 4.6%, respectively, HR 2.00, 95% CI 1.02-3.70). CONCLUSIONS: Following heart valve surgery, the risk of recurrent IE was significantly higher than the risk of first-time IE.
OBJECTIVE:Infective endocarditis (IE) may require heart valve surgery. It is well known that heart valve surgery itself and previous IE predispose to IE. However, data are sparse on whether the risk of IE is different among patients undergoing valve surgery due to IE and other causes (i.e. recurrent vs. first-time IE). METHODS: Using Danish nationwide registries, patients undergoing left-sided heart valve surgery in the course of an IE hospitalization (1996-2017) were identified and matched with controls undergoing left-sided heart valve surgery due to another cause than IE in a 1:1 ratio. Patients were stratified according to type of surgical valve intervention and affected valve. The comparative risk of recurrent vs. first-time IE was assessed by cumulative incidence curves and multivariable Cox regression analyses. RESULTS: The study population comprised 971 patients with a first-time admission for IE requiring heart valve surgery matched with 971 controls undergoing heart valve surgery due to other causes than IE. The risk of recurrent IE was significantly higher than the risk of first-time IE following heart valve surgery (5.5% and 3.0% by 10 years, hazard ratio (HR) 1.66, 95% confidence interval (CI) 1.02-2.70). The risk of IE recurrence was not significantly different comparing valve replacement and valve repair (5.5% and 5.3%, respectively, HR 1.60, 95% CI 0.71-3.60). Yet, the risk of IE recurrence was significantly higher among patients with biological versus mechanical prostheses (6.3% and 4.6%, respectively, HR 2.00, 95% CI 1.02-3.70). CONCLUSIONS: Following heart valve surgery, the risk of recurrent IE was significantly higher than the risk of first-time IE.
Authors: Johan S Bundgaard; Kasper Iversen; Mia Pries-Heje; Nikolaj Ihlemann; Sabine U Gill; Trine Madsen; Hanne Elming; Jonas A Povlsen; Niels E Bruun; Dan E Høfsten; Kurt Fuursted; Jens J Christensen; Martin Schultz; Flemming Rosenvinge; Jannik Helweg-Larsen; Lars Køber; Christian Torp-Pedersen; Emil L Fosbøl; Niels Tønder; Claus Moser; Henning Bundgaard; Ulrik M Mogensen Journal: Qual Life Res Date: 2022-03-29 Impact factor: 3.440
Authors: Eva Havers-Borgersen; Emil L Fosbøl; Jawad H Butt; Jeppe K Petersen; Andreas Dalsgaard; Frederik Kyhl; Morten Schou; Matthew Phelps; Kristian Kragholm; Gunnar H Gislason; Christian Torp-Pedersen; Lars Køber; Lauge Østergaard Journal: Int J Cardiol Heart Vasc Date: 2020-11-06
Authors: Christina Armstrong; Tim Christian Kuhn; Florian Leuschner; Alexandra Heininger; Matthias Dufner; Philipp Ehlermann; Stefan Zimmermann; Christoph Lichtenstern; Jasmin Soethoff; Hugo A Katus Journal: Clin Res Cardiol Date: 2020-06-02 Impact factor: 5.460