Johan S Bundgaard1, Kasper Iversen2,3, Mia Pries-Heje4, Nikolaj Ihlemann4, Sabine U Gill5, Trine Madsen6, Hanne Elming7, Jonas A Povlsen8, Niels E Bruun7,9,10, Dan E Høfsten4, Kurt Fuursted11, Jens J Christensen12, Martin Schultz2, Flemming Rosenvinge13, Jannik Helweg-Larsen14, Lars Køber4,3, Christian Torp-Pedersen6,15, Emil L Fosbøl4, Niels Tønder16, Claus Moser17,18, Henning Bundgaard4,3, Ulrik M Mogensen4,7. 1. Department of Cardiology, The Heart Center, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark. johan.skov.bundgaard.01@regionh.dk. 2. Department of Cardiology, Herlev-Gentofte University Hospital, Copenhagen, Denmark. 3. Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. 4. Department of Cardiology, The Heart Center, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark. 5. Department of Cardiology, Odense University Hospital, Odense, Denmark. 6. Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark. 7. Department of Cardiology, Zealand University Hospital, Roskilde, Denmark. 8. Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark. 9. Institute of Clinical Medicine, Copenhagen University, Copenhagen, Denmark. 10. Clinical Institute, Aalborg University, Aalborg, Denmark. 11. Department of Bacteria, Parasites and Fungi, Statens Serum Institute, Copenhagen, Denmark. 12. The Regional Department of Clinical Microbiology, Region Zealand Slagelse Hospital, Region Zealand, Denmark. 13. Department of Clinical Microbiology, Odense University Hospital, Odense, Denmark. 14. Department of Infectious Diseases, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark. 15. Department of Cardiology, Nordsjaellands Hospital, Hillerød, Denmark. 16. Department of Cardiology, North Zealand University Hospital, Hillerød, Denmark. 17. Department of Clinical Microbiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. 18. Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Abstract
PURPOSE: Self-assessed poor health status is associated with increased risk of mortality in several cardiovascular conditions, but has not been investigated in patients with endocarditis. We examined health status and mortality in patients with endocarditis. METHODS: This is a re-specified substudy of the randomized POET endocarditis trial, which included 400 patients. Patients completed the single-question self-assessed health status from the Short-Form 36 questionnaire at time of randomization and were categorized as having poor or non-poor (excellent/very good, good, or fair) health status. Self-assessed health status and all-cause mortality were examined by a Cox regression model. RESULTS: Self-assessed health status was completed by 266 (67%) patients with a mean age of 68.0 years (± 11.8), 54 (20%) were females, and 86 (32%) had one or more major concurrent medical conditions besides endocarditis. The self-assessed health status distribution was poor (n = 21, 8%) and non-poor (n = 245, 92%). The median follow-up was 3.3 years and death occurred in 9 (43%) and 48 (20%) patients reporting poor and non-poor health status, respectively, and mortality rates [mortality/100 person-years, 95% confidence interval (CI)] were 18.1 (95% CI 9.4-34.8) and 5.4 (95% CI 4.1-7.2), i.e., the crude hazard ratio for death was 3.4 (95% CI: 1.7-7.0, p < 0.01). CONCLUSION: Self-assessed poor health status compared with non-poor health status as assessed by a single question was associated with a threefold increased long-term mortality in patients with endocarditis. POET ClinicalTrials.gov number, NCT01375257. TRIAL REGISTRY: POET ClinicalTrials.gov number, NCT01375257.
PURPOSE: Self-assessed poor health status is associated with increased risk of mortality in several cardiovascular conditions, but has not been investigated in patients with endocarditis. We examined health status and mortality in patients with endocarditis. METHODS: This is a re-specified substudy of the randomized POET endocarditis trial, which included 400 patients. Patients completed the single-question self-assessed health status from the Short-Form 36 questionnaire at time of randomization and were categorized as having poor or non-poor (excellent/very good, good, or fair) health status. Self-assessed health status and all-cause mortality were examined by a Cox regression model. RESULTS: Self-assessed health status was completed by 266 (67%) patients with a mean age of 68.0 years (± 11.8), 54 (20%) were females, and 86 (32%) had one or more major concurrent medical conditions besides endocarditis. The self-assessed health status distribution was poor (n = 21, 8%) and non-poor (n = 245, 92%). The median follow-up was 3.3 years and death occurred in 9 (43%) and 48 (20%) patients reporting poor and non-poor health status, respectively, and mortality rates [mortality/100 person-years, 95% confidence interval (CI)] were 18.1 (95% CI 9.4-34.8) and 5.4 (95% CI 4.1-7.2), i.e., the crude hazard ratio for death was 3.4 (95% CI: 1.7-7.0, p < 0.01). CONCLUSION: Self-assessed poor health status compared with non-poor health status as assessed by a single question was associated with a threefold increased long-term mortality in patients with endocarditis. POET ClinicalTrials.gov number, NCT01375257. TRIAL REGISTRY: POET ClinicalTrials.gov number, NCT01375257.
Authors: Kasper Iversen; Nikolaj Ihlemann; Sabine U Gill; Trine Madsen; Hanne Elming; Kaare T Jensen; Niels E Bruun; Dan E Høfsten; Kurt Fursted; Jens J Christensen; Martin Schultz; Christine F Klein; Emil L Fosbøll; Flemming Rosenvinge; Henrik C Schønheyder; Lars Køber; Christian Torp-Pedersen; Jannik Helweg-Larsen; Niels Tønder; Claus Moser; Henning Bundgaard Journal: N Engl J Med Date: 2018-08-28 Impact factor: 91.245
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