Literature DB >> 32184946

A Medicinal Chemist's Journey at the National Institutes of Health One Molecule at a Time.

Amy Hauck Newman1.   

Abstract

Medicinal chemistry is a small but critical discipline that is integrated into several institutes across the National Institutes of Health, including the National Institute on Drug Abuse. I have had the opportunity and privilege to contribute novel small molecules that have opened opportunities for drug discovery, especially targeted to underserved populations who suffer from substance use disorders.
Copyright © 2020 American Chemical Society.

Year:  2020        PMID： 32184946      PMCID： PMC7073881          DOI： 10.1021/acsmedchemlett.9b00478

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  11 in total

1.  Cocaine receptors on dopamine transporters are related to self-administration of cocaine.

Authors:  M C Ritz; R J Lamb; S R Goldberg; M J Kuhar
Journal:  Science       Date:  1987-09-04       Impact factor: 47.728

2.  Dopamine D3R antagonist VK4-116 attenuates oxycodone self-administration and reinstatement without compromising its antinociceptive effects.

Authors:  Zhi-Bing You; Guo-Hua Bi; Ewa Galaj; Vivek Kumar; Jianjing Cao; Alexandra Gadiano; Rana Rais; Barbara S Slusher; Eliot L Gardner; Zheng-Xiong Xi; Amy Hauck Newman
Journal:  Neuropsychopharmacology       Date:  2018-11-27       Impact factor: 7.853

3.  Novel 4'-substituted and 4',4"-disubstituted 3 alpha-(diphenylmethoxy)tropane analogs as potent and selective dopamine uptake inhibitors.

Authors:  A H Newman; R H Kline; A C Allen; S Izenwasser; C George; J L Katz
Journal:  J Med Chem       Date:  1995-09-29       Impact factor: 7.446

4.  Novel 3 alpha-(diphenylmethoxy)tropane analogs: potent dopamine uptake inhibitors without cocaine-like behavioral profiles.

Authors:  A H Newman; A C Allen; S Izenwasser; J L Katz
Journal:  J Med Chem       Date:  1994-07-22       Impact factor: 7.446

5.  Novel 1-phenylcycloalkanecarboxylic acid derivatives as potential anticonvulsant agents.

Authors:  S N Calderon; A H Newman; F C Tortella
Journal:  J Med Chem       Date:  1991-11       Impact factor: 7.446

6.  Highly Selective Dopamine D3 Receptor (D3R) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment.

Authors:  Vivek Kumar; Alessandro Bonifazi; Michael P Ellenberger; Thomas M Keck; Elie Pommier; Rana Rais; Barbara S Slusher; Eliot Gardner; Zhi-Bing You; Zheng-Xiong Xi; Amy Hauck Newman
Journal:  J Med Chem       Date:  2016-08-10       Impact factor: 7.446

7.  Novel 1-phenylcycloalkanecarboxylic acid derivatives are potent and selective sigma 1 ligands.

Authors:  S N Calderon; S Izenwasser; B Heller; J S Gutkind; M V Mattson; T P Su; A H Newman
Journal:  J Med Chem       Date:  1994-07-22       Impact factor: 7.446

8.  Synthesis and evaluation of 3-substituted 17-methylmorphinan analogs as potential anticonvulsant agents.

Authors:  A H Newman; K Bevan; N Bowery; F C Tortella
Journal:  J Med Chem       Date:  1992-10-30       Impact factor: 7.446

9.  2016 Philip S. Portoghese Medicinal Chemistry Lectureship: Designing Bivalent or Bitopic Molecules for G-Protein Coupled Receptors. The Whole Is Greater Than the Sum of Its Parts.

Authors:  Amy Hauck Newman; Francisco O Battiti; Alessandro Bonifazi
Journal:  J Med Chem       Date:  2019-09-24       Impact factor: 7.446

10.  Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors.

Authors:  Jianjing Cao; Rachel D Slack; Oluyomi M Bakare; Caitlin Burzynski; Rana Rais; Barbara S Slusher; Theresa Kopajtic; Alessandro Bonifazi; Michael P Ellenberger; Hideaki Yano; Yi He; Guo-Hua Bi; Zheng-Xiong Xi; Claus J Loland; Amy Hauck Newman
Journal:  J Med Chem       Date:  2016-11-28       Impact factor: 7.446
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