Pengcheng Liu1, Qiuwen Tan2, Yanlin Jiang3, Qing Lü1. 1. Department of Breast Surgery, Clinical Research Center for Breast Disease, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China. 2. Department of Breast Surgery, Clinical Research Center for Breast Disease, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China;Laboratory of Stem Cell and Tissue Engineering, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China. 3. Laboratory of Stem Cell and Tissue Engineering, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.
Abstract
OBJECTIVE: To explore the research progress of the cell sources and related signaling pathways of the wound-induced hair follicle neogenesis (WIHN) in recent years. METHODS: The literature related to WIHN in recent years was reviewed, and the cell sources and molecular mechanism were summarized and discussed. RESULTS: Current research shows that WIHN is a rare regeneration phenomenon in the skin of adult mammals, with multiple cell origins, both hair follicle stem cells and epithelial stem cells around the wound. Its molecular mechanism is complicated, which is regulated by many signaling pathways. Besides, the process is closely related to the immune response, the immunocytes and their related cytokines provide suitable conditions for this process. CONCLUSION: There are still many unsolved problems on the cellular origins and molecular mechanisms of the WIHN. Further study on the mechanisms will enhance the understanding of adult mammals' hair follicle regeneration and may provide new strategy for functional healing of the human skin.
OBJECTIVE: To explore the research progress of the cell sources and related signaling pathways of the wound-induced hair follicle neogenesis (WIHN) in recent years. METHODS: The literature related to WIHN in recent years was reviewed, and the cell sources and molecular mechanism were summarized and discussed. RESULTS: Current research shows that WIHN is a rare regeneration phenomenon in the skin of adult mammals, with multiple cell origins, both hair follicle stem cells and epithelial stem cells around the wound. Its molecular mechanism is complicated, which is regulated by many signaling pathways. Besides, the process is closely related to the immune response, the immunocytes and their related cytokines provide suitable conditions for this process. CONCLUSION: There are still many unsolved problems on the cellular origins and molecular mechanisms of the WIHN. Further study on the mechanisms will enhance the understanding of adult mammals' hair follicle regeneration and may provide new strategy for functional healing of the human skin.
Authors: Chengxiang Fan; Michael A Luedtke; Stephen M Prouty; Michelle Burrows; Nikiforos Kollias; George Cotsarelis Journal: Skin Res Technol Date: 2011-04-15 Impact factor: 2.365
Authors: Sun-Mi Park; Raquel P Deering; Yuheng Lu; Patrick Tivnan; Steve Lianoglou; Fatima Al-Shahrour; Benjamin L Ebert; Nir Hacohen; Christina Leslie; George Q Daley; Christopher J Lengner; Michael G Kharas Journal: J Exp Med Date: 2014-01-06 Impact factor: 14.307