Literature DB >> 29310861

Never too old to regenerate? Wound induced hair follicle neogenesis after secondary intention healing in a geriatric patient.

Tak-Wah Wong1, Michael Hughes2, Szu-Han Wang3.   

Abstract

Wound healing is a natural process to restore the structure and function of injured or diseased tissues. Repair of a skin wound usually leads to a scar while regeneration implies fully recovery of function and structure of the damaged tissue. Adult skin wound usually heals with scar while fetal skin heals scarless. Hair regeneration in elderly scalp wound has never been observed. We reported an 80-year-old patient with a large wound on the scalp after excision of a basal cell carcinoma healed by secondary intention wound healing. The patient's wound healed very well aesthetically. Interestingly, on approximate post wound day 180, a hair was observed to be growing towards the surface and eventually erupted in the center of the wound. The hair remained black at 42-month follow-up. This case demonstrated that neogenesis of hair is possible even in geriatric patient. To the best of our knowledge, this is the first report of hair regrow in human skin after wound healing.
Copyright © 2018 Tissue Viability Society. Published by Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Basal cell carcinoma; Hair follicle; Regeneration; Secondary intention healing

Mesh:

Year:  2018        PMID: 29310861     DOI: 10.1016/j.jtv.2018.01.001

Source DB:  PubMed          Journal:  J Tissue Viability        ISSN: 0965-206X            Impact factor:   2.932


  2 in total

Review 1.  Through the lens of hair follicle neogenesis, a new focus on mechanisms of skin regeneration after wounding.

Authors:  Eric M Wier; Luis A Garza
Journal:  Semin Cell Dev Biol       Date:  2019-10-10       Impact factor: 7.727

Review 2.  [Wound-induced hair follicle neogenesis: a new perspective on hair follicles regeneration in adult mammals].

Authors:  Pengcheng Liu; Qiuwen Tan; Yanlin Jiang; Qing Lü
Journal:  Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi       Date:  2020-03-15
  2 in total

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