A Guermazi1, M Jarraya2, J A Lynch3, D T Felson4, M Clancy4, M Nevitt3, C E Lewis5, J Torner6, T Neogi4. 1. Department of Radiology, Boston University School of Medicine, Boston University, Boston, MA, USA. Electronic address: guermazi@bu.edu. 2. Department of Radiology, Boston University School of Medicine, Boston University, Boston, MA, USA; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. 3. Department of Epidemiology, University of California San Francisco, CA, USA. 4. Department of Medicine, Boston University School of Medicine, Boston University, Boston, MA, USA. 5. Department of Epidemiology, University of Alabama at Birmingham, AL, USA. 6. Department of Epidemiology, College of Public Health, University of Iowa, IA, USA.
Abstract
BACKGROUND: The role of intra-articular mineralization in osteoarthritis (OA) is unclear. Its understanding may potentially advance our knowledge of knee OA pathogenesis. We describe and assess the reliability of a novel computed tomography (CT) scoring system, the Boston University Calcium Knee Score (BUCKS) for evaluating intra-articular mineralization. METHODS: We included subjects from the most recent study visit of the Multicenter Osteoarthritis Study (MOST) Study, a NIH-funded longitudinal cohort of community-dwelling older adults with or at risk of knee OA. All subjects underwent CT of bilateral knees. Each knee was scored at 28 scored locations (14 for cartilage, 6 for menisci, 6 for ligaments, 1 for joint capsule, and 1 popliteal-tibial vessels). A single musculoskeletal radiologist scored cartilage and meniscus subregions, as well as vascular calcifications assigning to each a score ranging from 0 to 3. The joint capsule, medial and lateral posterior meniscal roots, anterior cruciate ligament (ACL)/posterior cruciate ligament (PCL) and 2 collateral ligaments [medial collateral ligament (MCL)/lateral collateral ligament (LCL)] were each scored 0 or 1 for absence or presence of mineralization. To assess reliability, 31 subject CTs were reread 12 weeks later by the same reader and by a second reader and agreement was evaluated using a weighted kappa. RESULTS: The intra-reader reliability ranged from 0.92 for ligaments to 1.0 for joint capsule. The inter-reader reliability ranged from 0.94 for cartilage and ligaments, to 1.0 for joint capsule. CONCLUSION: BUCKS demonstrated excellent reliability and is a potentially useful CT-based tool for studying the role of calcium crystals in knee OA.
BACKGROUND: The role of intra-articular mineralization in osteoarthritis (OA) is unclear. Its understanding may potentially advance our knowledge of knee OA pathogenesis. We describe and assess the reliability of a novel computed tomography (CT) scoring system, the Boston University Calcium Knee Score (BUCKS) for evaluating intra-articular mineralization. METHODS: We included subjects from the most recent study visit of the Multicenter Osteoarthritis Study (MOST) Study, a NIH-funded longitudinal cohort of community-dwelling older adults with or at risk of knee OA. All subjects underwent CT of bilateral knees. Each knee was scored at 28 scored locations (14 for cartilage, 6 for menisci, 6 for ligaments, 1 for joint capsule, and 1 popliteal-tibial vessels). A single musculoskeletal radiologist scored cartilage and meniscus subregions, as well as vascular calcifications assigning to each a score ranging from 0 to 3. The joint capsule, medial and lateral posterior meniscal roots, anterior cruciate ligament (ACL)/posterior cruciate ligament (PCL) and 2 collateral ligaments [medial collateral ligament (MCL)/lateral collateral ligament (LCL)] were each scored 0 or 1 for absence or presence of mineralization. To assess reliability, 31 subject CTs were reread 12 weeks later by the same reader and by a second reader and agreement was evaluated using a weighted kappa. RESULTS: The intra-reader reliability ranged from 0.92 for ligaments to 1.0 for joint capsule. The inter-reader reliability ranged from 0.94 for cartilage and ligaments, to 1.0 for joint capsule. CONCLUSION: BUCKS demonstrated excellent reliability and is a potentially useful CT-based tool for studying the role of calcium crystals in knee OA.
Authors: Debdut Biswas; Jesse E Bible; Michael Bohan; Andrew K Simpson; Peter G Whang; Jonathan N Grauer Journal: J Bone Joint Surg Am Date: 2009-08 Impact factor: 5.284
Authors: Beth A Derfus; Jason B Kurian; Jeffrey J Butler; Laureen J Daft; Guillermo F Carrera; Lawrence M Ryan; Ann K Rosenthal Journal: J Rheumatol Date: 2002-03 Impact factor: 4.666
Authors: Victoria G Barskova; Fatima M Kudaeva; Liliya A Bozhieva; Alexander V Smirnov; Alexander V Volkov; Evgenii L Nasonov Journal: Rheumatology (Oxford) Date: 2013-02-04 Impact factor: 7.580