Nekma Meah1, Dmitri Wall1, Katherine York2, Bevin Bhoyrul1, Laita Bokhari1, Daniel Asz Sigall3, Wilma F Bergfeld4, Regina C Betz5, Ulrike Blume-Peytavi6, Valerie Callender7, Vijaya Chitreddy1, Andrea Combalia8, George Cotsarelis9, Brittany Craiglow10, Jeff Donovan11, Samantha Eisman1, Paul Farrant12, Jack Green13, Ramon Grimalt14, Matthew Harries15, Maria Hordinsky16, Alan D Irvine17, Satoshi Itami18, Victoria Jolliffe19, Brett King20, Won-Soo Lee21, Amy McMichael22, Andrew Messenger23, Paradi Mirmirani24, Elise Olsen25, Seth J Orlow26, Bianca Maria Piraccini27, Adriana Rakowska28, Pascal Reygagne29, Janet L Roberts30, Lidia Rudnicka28, Jerry Shapiro31, Pooja Sharma1, Antonella Tosti32, Annika Vogt33, Martin Wade34, Leona Yip35, Abraham Zlotogorski36, Rodney Sinclair37. 1. Sinclair Dermatology, East Melbourne, Melbourne, Australia. 2. Netcare Greenacres Hospital, Port Elizabeth, South Africa. 3. Dermalomas Clinic, Mexico City, Mexico. 4. Departments of Dermatology and Pathology, Cleveland Clinic, Cleveland, Ohio. 5. Institute of Human Genetics, School of Medicine & University Hospital Bonn, University of Bonn, Bonn, Germany. 6. Department of Dermatology and Allergy, Clinical Research Center for Hair and Skin Science, Charité-Universitätsmedizin Berlin, Berlin, Germany. 7. Howard University College of Medicine, Washington, DC. 8. Department of Dermatology, Hospital Clinic de Barcelona, Barcelona, Spain. 9. Department of Dermatology University of Pennsylvania School of Medicine Philadelphia, Philadelphia, Pennsylvania. 10. Dermatology Physicians of Connecticut, Fairfield, Connecticut. 11. Donovan Hair Clinic, Whistler, Canada. 12. Brighton and Sussex University Hospitals Trust, Brighton, United Kingdom. 13. St. Vincent's Hospital, Melbourne, Australia. 14. Facultat de Medicina i Ciències de la Salut, Universitat Internacional de Catalunya, Sant Cugat del Vallès, Spain. 15. Department of Dermatology, Salford Royal NHS Foundation Trust, Manchester, United Kingdom. 16. Dermatology, M Health Fairview Discovery Pediatric Specialty Clinic, Minneapolis, Minnesota. 17. St. James's Hospital and National and International Sin Registry (NISR) Solutions, Dublin, Ireland. 18. Department of Dermatology, Oita University, Yufu City, Japan. 19. Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom. 20. Yale School of Medicine, Yale Dermatology, Middlebury, Connecticut. 21. Department of Dermatology Yonsei University Wonju College of Medicine, Wonju, Republic of Korea. 22. Department of Dermatology, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina. 23. Department of Infection, Immunity, and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom. 24. The Permanente Medical Group, Vallejo, California. 25. Duke Dermatology Clinic, Durham, North Carolina. 26. Director of Pediatric Dermatology, The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York; Department of Pediatrics, New York University Medical Center, New York, New York. 27. Deputy for International Relations, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum University of Bologna, Bologna, Italy. 28. Department of Dermatology, Medical University of Warsaw, Warsaw, Poland. 29. Cabinet Pascal Reygagne (Lecourbe), Paris, France. 30. Northwest Dermatology Institute, Portland, Oregon. 31. Director of Pediatric Dermatology, The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York. 32. Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida. 33. Department of Dermatology, Venerology and Allergology, Charité Universitätsmedizin Berlin, Berlin, Germany. 34. The London Skin and Hair Clinic, London, United Kingdom. 35. Gabba Dermatology, Brisbane, Australia. 36. Faculty of Medicine, Department of Dermatology, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel. 37. Sinclair Dermatology, East Melbourne, Melbourne, Australia. Electronic address: rodneyds@unimelb.edu.au.
Abstract
BACKGROUND: A systematic review failed to identify any systemic therapy used in alopecia areata (AA) where use is supported by robust evidence from high-quality randomized controlled trials. OBJECTIVE: To produce an international consensus statement on the use and utility of various treatments for AA. METHODS: Fifty hair experts from 5 continents were invited to participate in a 3-round Delphi process. Agreement of 66% or greater was considered consensus. RESULTS: In the first round, consensus was achieved in 22 of 423 (5%) questions. After a face-to-face meeting in round 3, overall, consensus was achieved for only 130 (33%) treatment-specific questions. There was greater consensus for intralesional treatment of AA (19 [68%]) followed by topical treatment (25 [43%]). Consensus was achieved in 45 (36%) questions pertaining to systemic therapies in AA. The categories with the least consensus were phototherapy and nonprescription therapies. LIMITATIONS: The study included a comprehensive list of systemic treatments for AA but not all treatments used. CONCLUSION: Despite divergent opinions among experts, consensus was achieved on a number of pertinent questions. The concluding statement also highlights areas where expert consensus is lacking and where an international patient registry could enable further research.
BACKGROUND: A systematic review failed to identify any systemic therapy used in alopecia areata (AA) where use is supported by robust evidence from high-quality randomized controlled trials. OBJECTIVE: To produce an international consensus statement on the use and utility of various treatments for AA. METHODS: Fifty hair experts from 5 continents were invited to participate in a 3-round Delphi process. Agreement of 66% or greater was considered consensus. RESULTS: In the first round, consensus was achieved in 22 of 423 (5%) questions. After a face-to-face meeting in round 3, overall, consensus was achieved for only 130 (33%) treatment-specific questions. There was greater consensus for intralesional treatment of AA (19 [68%]) followed by topical treatment (25 [43%]). Consensus was achieved in 45 (36%) questions pertaining to systemic therapies in AA. The categories with the least consensus were phototherapy and nonprescription therapies. LIMITATIONS: The study included a comprehensive list of systemic treatments for AA but not all treatments used. CONCLUSION: Despite divergent opinions among experts, consensus was achieved on a number of pertinent questions. The concluding statement also highlights areas where expert consensus is lacking and where an international patient registry could enable further research.
Authors: Esther E Freeman; Grace C Chamberlin; Devon E McMahon; George J Hruza; Dmitri Wall; Nekma Meah; Rodney Sinclair; Esther A Balogh; Steven R Feldman; Michelle A Lowes; Angelo V Marzano; Haley B Naik; Leslie Castelo-Soccio; Irene Lara-Corrales; Kelly M Cordoro; Satveer K Mahil; Christopher E M Griffiths; Catherine H Smith; Alan D Irvine; Phyllis I Spuls; Carsten Flohr; Lars E French Journal: Dermatol Clin Date: 2021-05-31 Impact factor: 3.478
Authors: Dmitri Wall; Raed Alhusayen; Bernd Arents; Christian Apfelbacher; Esther A Balogh; Laita Bokhari; Manja Bloem; Angela L Bosma; Tim Burton; Leslie Castelo-Soccio; Nicole Fagan; Steven R Feldman; Godfrey Fletcher; Carsten Flohr; Esther Freeman; Lars E French; Christopher E M Griffiths; George J Hruza; John R Ingram; Michael D Kappelman; Irene Lara-Corrales; Henry W Lim; Nekma Meah; Devon E McMahon; Satveer K Mahil; Ian McNicoll; Annelie Musters; Haley B Naik; Rodney Sinclair; Catherine H Smith; Phyllis Spuls; Desmond J Tobin; Katherine York; Alan D Irvine Journal: Clin Dermatol Date: 2021-04-06 Impact factor: 3.541
Authors: Brett A King; Maryanne M Senna; Manabu Ohyama; Antonella Tosti; Rodney D Sinclair; Susan Ball; Justin M Ko; Marc Glashofer; Rodrigo Pirmez; Jerry Shapiro Journal: Dermatol Ther (Heidelb) Date: 2022-03-31
Authors: Fanni Adél Meznerics; Kata Illés; Fanni Dembrovszky; Péter Fehérvári; Lajos Vince Kemény; Kata Dorottya Kovács; Norbert Miklós Wikonkál; Dezső Csupor; Péter Hegyi; András Bánvölgyi Journal: Biomedicines Date: 2022-07-29
Authors: Maryanne Senna; Justin Ko; Antonella Tosti; Emily Edson-Heredia; D Christian Fenske; Amy K Ellinwood; Maria Jose Rueda; Baojin Zhu; Brett King Journal: Adv Ther Date: 2021-07-22 Impact factor: 3.845