OBJECTIVE: To provide reference data regarding the frequency and safety of elective termination of pregnancy in women with autoimmune rheumatic diseases followed up in 2 referral databases. METHODS: Two large databases, one from an autoimmune rheumatic disease referral clinical practice with a known interest in pregnancy (the Barbara Volcker Center for Women and Rheumatic Disease [BVC]), and one from an observational study of systemic lupus erythematosus- and antiphospholipid antibody-associated pregnancies (Predictors of Pregnancy Outcome: Biomarkers in Antiphospholipid Antibody Syndrome and Systemic Lupus Erythematosus [PROMISSE]), were interrogated for histories of prior elective termination of pregnancy and complications related to incident pregnancy termination. RESULTS: Of women who had had prior pregnancies, 21.7% of 1,307 in the BVC database and 25.3% of 297 in the PROMISSE database gave histories of 1-5 prior elective terminations of pregnancy; BVC patients reported no flares or hospitalizable complications due to pregnancy termination. Of 674 incident pregnancies, termination for fetal or maternal reasons was recommended for 15 (2%); of these, 2 fetuses died before the procedure was carried out and 1 woman declined termination and, though gravely ill, successfully delivered. She died of cardiomyopathy 3 years later. CONCLUSION: Many patients with autoimmune rheumatic disease undergo elective termination of pregnancy; few report complications. In medically indicated termination of pregnancy, there are no adverse signals of unusual complications or disease flare.
OBJECTIVE: To provide reference data regarding the frequency and safety of elective termination of pregnancy in women with autoimmune rheumatic diseases followed up in 2 referral databases. METHODS: Two large databases, one from an autoimmune rheumatic disease referral clinical practice with a known interest in pregnancy (the Barbara Volcker Center for Women and Rheumatic Disease [BVC]), and one from an observational study of systemic lupus erythematosus- and antiphospholipid antibody-associated pregnancies (Predictors of Pregnancy Outcome: Biomarkers in Antiphospholipid Antibody Syndrome and Systemic Lupus Erythematosus [PROMISSE]), were interrogated for histories of prior elective termination of pregnancy and complications related to incident pregnancy termination. RESULTS: Of women who had had prior pregnancies, 21.7% of 1,307 in the BVC database and 25.3% of 297 in the PROMISSE database gave histories of 1-5 prior elective terminations of pregnancy; BVC patients reported no flares or hospitalizable complications due to pregnancy termination. Of 674 incident pregnancies, termination for fetal or maternal reasons was recommended for 15 (2%); of these, 2 fetuses died before the procedure was carried out and 1 woman declined termination and, though gravely ill, successfully delivered. She died of cardiomyopathy 3 years later. CONCLUSION: Many patients with autoimmune rheumatic disease undergo elective termination of pregnancy; few report complications. In medically indicated termination of pregnancy, there are no adverse signals of unusual complications or disease flare.
Authors: Michael D Lockshin; Mimi Kim; Carl A Laskin; Marta Guerra; D Ware Branch; Joan Merrill; Michelle Petri; T Flint Porter; Lisa Sammaritano; Mary D Stephenson; Jill Buyon; Jane E Salmon Journal: Arthritis Rheum Date: 2012-07
Authors: Jill P Buyon; Mimi Y Kim; Marta M Guerra; Carl A Laskin; Michelle Petri; Michael D Lockshin; Lisa Sammaritano; D Ware Branch; T Flint Porter; Allen Sawitzke; Joan T Merrill; Mary D Stephenson; Elisabeth Cohn; Lamya Garabet; Jane E Salmon Journal: Ann Intern Med Date: 2015-08-04 Impact factor: 25.391
Authors: Lisa R Sammaritano; Bonnie L Bermas; Eliza E Chakravarty; Christina Chambers; Megan E B Clowse; Michael D Lockshin; Wendy Marder; Gordon Guyatt; D Ware Branch; Jill Buyon; Lisa Christopher-Stine; Rachelle Crow-Hercher; John Cush; Maurice Druzin; Arthur Kavanaugh; Carl A Laskin; Lauren Plante; Jane Salmon; Julia Simard; Emily C Somers; Virginia Steen; Sara K Tedeschi; Evelyne Vinet; C Whitney White; Jinoos Yazdany; Medha Barbhaiya; Brittany Bettendorf; Amanda Eudy; Arundathi Jayatilleke; Amit Aakash Shah; Nancy Sullivan; Laura L Tarter; Mehret Birru Talabi; Marat Turgunbaev; Amy Turner; Kristen E D'Anci Journal: Arthritis Rheumatol Date: 2020-02-23 Impact factor: 10.995
Authors: Cecile M Yelnik; Carl A Laskin; T Flint Porter; D Ware Branch; Jill P Buyon; Marta M Guerra; Michael D Lockshin; Michelle Petri; Joan T Merrill; Lisa R Sammaritano; Mimi Y Kim; Jane E Salmon Journal: Lupus Sci Med Date: 2016-01-12