Literature DB >> 32158929

How to starve cancer cells when nutrients are abundant.

Hamidullah Khan1, Stefan M Schieke1,2.   

Abstract

Metabolic flexibility represents a potential point of attack for novel cancer treatments. We recently described the signaling mechanism inducing a metabolic shift in response to metformin and phenformin in leukemia and lymphoma cells. Enhanced glucose utilization was critically dependent on mitochondrial stress signaling/hypoxia-inducible factor-1α representing a therapeutic vulnerability.
© 2020 Taylor & Francis Group, LLC.

Entities:  

Keywords:  HIF-1a; Metformin; metabolic flexibility; mitochondria; phenformin

Year:  2020        PMID： 32158929      PMCID： PMC7051138          DOI： 10.1080/23723556.2020.1718475

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Metformin as an Anticancer Agent.

Authors:  Ales Vancura; Pengli Bu; Madhura Bhagwat; Joey Zeng; Ivana Vancurova
Journal:  Trends Pharmacol Sci       Date:  2018-08-24       Impact factor: 14.819

Review 2.  Understanding the Intersections between Metabolism and Cancer Biology.

Authors:  Matthew G Vander Heiden; Ralph J DeBerardinis
Journal:  Cell       Date:  2017-02-09       Impact factor: 41.582

3.  Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers.

Authors:  Xiaojing Liu; Iris L Romero; Lacey M Litchfield; Ernst Lengyel; Jason W Locasale
Journal:  Cell Metab       Date:  2016-10-13       Impact factor: 27.287

Review 4.  Mitochondria and Cancer.

Authors:  Sejal Vyas; Elma Zaganjor; Marcia C Haigis
Journal:  Cell       Date:  2016-07-28       Impact factor: 41.582

5.  Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia.

Authors:  Siroon Bekkering; Lotte C A Stiekema; Sophie Bernelot Moens; Simone L Verweij; Boris Novakovic; Koen Prange; Miranda Versloot; Jeanine E Roeters van Lennep; Henk Stunnenberg; Menno de Winther; Erik S G Stroes; Leo A B Joosten; Mihai G Netea; Niels P Riksen
Journal:  Cell Metab       Date:  2019-06-13       Impact factor: 27.287

6.  Metabolic Rewiring in Response to Biguanides Is Mediated by mROS/HIF-1a in Malignant Lymphocytes.

Authors:  Hamidullah Khan; Ashish Anshu; Aman Prasad; Sushmita Roy; Justin Jeffery; Wasakorn Kittipongdaja; David T Yang; Stefan M Schieke
Journal:  Cell Rep       Date:  2019-12-03       Impact factor: 9.423

Review 7.  Otto Warburg's contributions to current concepts of cancer metabolism.

Authors:  Willem H Koppenol; Patricia L Bounds; Chi V Dang
Journal:  Nat Rev Cancer       Date:  2011-04-14       Impact factor: 60.716

Review 8.  A framework for examining how diet impacts tumour metabolism.

Authors:  Evan C Lien; Matthew G Vander Heiden
Journal:  Nat Rev Cancer       Date:  2019-09-17       Impact factor: 60.716

9.  Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.

Authors:  Kıvanç Birsoy; Richard Possemato; Franziska K Lorbeer; Erol C Bayraktar; Prathapan Thiru; Burcu Yucel; Tim Wang; Walter W Chen; Clary B Clish; David M Sabatini
Journal:  Nature       Date:  2014-03-16       Impact factor: 49.962

10.  Maintaining cytosolic aspartate levels is a major function of the TCA cycle in proliferating cells.

Authors:  H Furkan Alkan; Juliane G Bogner-Strauss
Journal:  Mol Cell Oncol       Date:  2019-07-09
  10 in total

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