Literature DB >> 31204280

Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia.

Siroon Bekkering1, Lotte C A Stiekema2, Sophie Bernelot Moens2, Simone L Verweij2, Boris Novakovic3, Koen Prange4, Miranda Versloot2, Jeanine E Roeters van Lennep5, Henk Stunnenberg6, Menno de Winther7, Erik S G Stroes2, Leo A B Joosten8, Mihai G Netea9, Niels P Riksen10.   

Abstract

Individuals with elevated LDL-cholesterol levels have an increased risk for cardiovascular disease. Despite lipid lowering strategies, however, a significant cardiovascular risk remains. Bekkering et al. show that monocytes from patients with familial hypercholesterolemia have a trained immunity phenotype and that lipid lowering with statins does not revert this pro-inflammatory phenotype.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Year:  2019        PMID： 31204280     DOI： 10.1016/j.cmet.2019.05.014

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  39 in total

1.  Immune cells that remember inflammation could offer treatment targets for atherosclerosis.

Authors:  Amanda B Keener
Journal:  Nature       Date:  2021-06       Impact factor: 49.962

2.  How to starve cancer cells when nutrients are abundant.

Authors:  Hamidullah Khan; Stefan M Schieke
Journal:  Mol Cell Oncol       Date:  2020-02-11

Review 3.  Trained Immunity as a Trigger for Atherosclerotic Cardiovascular Disease-A Literature Review.

Authors:  Natalia Anna Zieleniewska; Małgorzata Kazberuk; Małgorzata Chlabicz; Andrzej Eljaszewicz; Karol Kamiński
Journal:  J Clin Med       Date:  2022-06-12       Impact factor: 4.964

Review 4.  Asymptomatic hyperuricaemia: a silent activator of the innate immune system.

Authors:  Leo A B Joosten; Tania O Crişan; Petter Bjornstad; Richard J Johnson
Journal:  Nat Rev Rheumatol       Date:  2019-12-10       Impact factor: 20.543

5.  Chronic HIV infection induces transcriptional and functional reprogramming of innate immune cells.

Authors:  Wouter A van der Heijden; Lisa Van de Wijer; Farid Keramati; Wim Trypsteen; Sofie Rutsaert; Rob Ter Horst; Martin Jaeger; Hans Jpm Koenen; Hendrik G Stunnenberg; Irma Joosten; Paul E Verweij; Jan van Lunzen; Charles A Dinarello; Leo Ab Joosten; Linos Vandekerckhove; Mihai G Netea; André Jam van der Ven; Quirijn de Mast
Journal:  JCI Insight       Date:  2021-04-08

Review 6.  Targeting inflammation in atherosclerosis - from experimental insights to the clinic.

Authors:  Oliver Soehnlein; Peter Libby
Journal:  Nat Rev Drug Discov       Date:  2021-05-11       Impact factor: 84.694

7.  Pro-inflammatory Monocyte Phenotype During Acute Progression of Cerebral Small Vessel Disease.

Authors:  Marlies P Noz; Annemieke Ter Telgte; Kim Wiegertjes; Anil M Tuladhar; Charlotte Kaffa; Simone Kersten; Siroon Bekkering; Charlotte D C C van der Heijden; Alexander Hoischen; Leo A B Joosten; Mihai G Netea; Marco Duering; Frank-Erik de Leeuw; Niels P Riksen
Journal:  Front Cardiovasc Med       Date:  2021-05-13

Review 8.  The cholesterol pathway: impact on immunity and cancer.

Authors:  Ryan J King; Pankaj K Singh; Kamiya Mehla
Journal:  Trends Immunol       Date:  2022-01       Impact factor: 16.687

9.  Reply to Hu et al: Could there be detrimental effects of statin adjunctive TB therapy on immune responses?

Authors:  Noton K Dutta; Petros C Karakousis
Journal:  J Infect Dis       Date:  2020-06-29       Impact factor: 7.759

Review 10.  Targeting Trained Innate Immunity With Nanobiologics to Treat Cardiovascular Disease.

Authors:  Abraham J P Teunissen; Mandy M T van Leent; Geoffrey Prévot; Eliane E S Brechbühl; Carlos Pérez-Medina; Raphaël Duivenvoorden; Zahi A Fayad; Willem J M Mulder
Journal:  Arterioscler Thromb Vasc Biol       Date:  2021-04-22       Impact factor: 10.514
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