Literature DB >> 32158917

New models of large-cell neuroendocrine carcinoma and small-cell lung carcinoma.

Mirentxu Santos1,2,3.   

Abstract

High-grade neuroendocrine lung carcinomas (LCNEC, SCLC) are recalcitrant cancers for which no optimal management has been achieved. We have recently described two models of LCNEC and SCLC developed upon inactivation of 4 tumor suppressors genes (Rb1 (RB transcriptional corepressor 1), Rbl1 (RB transcriptional corepressor like 1), Pten (phosphatase and tensin homolog), Trp53 (transformation-related protein 53), which provide a suitable frame for preclinical intervention. A defined model for LCNEC had not been previously reported.
© 2020 Taylor & Francis Group, LLC.

Entities:  

Keywords:  LCNEC; Lung cancer; Pten; Rb1; Rbl1; SCLC; Trp53; cell of origin; molecular imaging; tumor suppressors

Year:  2020        PMID： 32158917      PMCID： PMC7051149          DOI： 10.1080/23723556.2019.1702413

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  8 in total

1.  Cell of origin of small cell lung cancer: inactivation of Trp53 and Rb1 in distinct cell types of adult mouse lung.

Authors:  Kate D Sutherland; Natalie Proost; Inge Brouns; Dirk Adriaensen; Ji-Ying Song; Anton Berns
Journal:  Cancer Cell       Date:  2011-06-14       Impact factor: 31.743

2.  Loss of p130 accelerates tumor development in a mouse model for human small-cell lung carcinoma.

Authors:  Bethany E Schaffer; Kwon-Sik Park; Gloria Yiu; Jamie F Conklin; Chenwei Lin; Deborah L Burkhart; Anthony N Karnezis; E Alejandro Sweet-Cordero; Julien Sage
Journal:  Cancer Res       Date:  2010-04-20       Impact factor: 12.701

3.  The comparative pathology of genetically engineered mouse models for neuroendocrine carcinomas of the lung.

Authors:  Adi F Gazdar; Trisha K Savage; Jane E Johnson; Anton Berns; Julien Sage; R Ilona Linnoila; David MacPherson; David G McFadden; Anna Farago; Tyler Jacks; William D Travis; Elisabeth Brambilla
Journal:  J Thorac Oncol       Date:  2015-04       Impact factor: 15.609

4.  Multiple cells-of-origin of mutant K-Ras-induced mouse lung adenocarcinoma.

Authors:  Kate D Sutherland; Ji-Ying Song; Min Chul Kwon; Natalie Proost; John Zevenhoven; Anton Berns
Journal:  Proc Natl Acad Sci U S A       Date:  2014-02-28       Impact factor: 11.205

Review 5.  Origins, genetic landscape, and emerging therapies of small cell lung cancer.

Authors:  Ekaterina A Semenova; Remco Nagel; Anton Berns
Journal:  Genes Dev       Date:  2015-07-15       Impact factor: 11.361

6.  Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors.

Authors:  Julie George; Vonn Walter; Martin Peifer; Ludmil B Alexandrov; Danila Seidel; Frauke Leenders; Lukas Maas; Christian Müller; Ilona Dahmen; Tiffany M Delhomme; Maude Ardin; Noemie Leblay; Graham Byrnes; Ruping Sun; Aurélien De Reynies; Anne McLeer-Florin; Graziella Bosco; Florian Malchers; Roopika Menon; Janine Altmüller; Christian Becker; Peter Nürnberg; Viktor Achter; Ulrich Lang; Peter M Schneider; Magdalena Bogus; Matthew G Soloway; Matthew D Wilkerson; Yupeng Cun; James D McKay; Denis Moro-Sibilot; Christian G Brambilla; Sylvie Lantuejoul; Nicolas Lemaitre; Alex Soltermann; Walter Weder; Verena Tischler; Odd Terje Brustugun; Marius Lund-Iversen; Åslaug Helland; Steinar Solberg; Sascha Ansén; Gavin Wright; Benjamin Solomon; Luca Roz; Ugo Pastorino; Iver Petersen; Joachim H Clement; Jörg Sänger; Jürgen Wolf; Martin Vingron; Thomas Zander; Sven Perner; William D Travis; Stefan A Haas; Magali Olivier; Matthieu Foll; Reinhard Büttner; David Neil Hayes; Elisabeth Brambilla; Lynnette Fernandez-Cuesta; Roman K Thomas
Journal:  Nat Commun       Date:  2018-03-13       Impact factor: 14.919

7.  Differential development of large-cell neuroendocrine or small-cell lung carcinoma upon inactivation of 4 tumor suppressor genes.

Authors:  Sara Lázaro; Miriam Pérez-Crespo; Corina Lorz; Alejandra Bernardini; Marta Oteo; Ana Belén Enguita; Eduardo Romero; Pilar Hernández; Laura Tomás; Miguel Ángel Morcillo; Jesús M Paramio; Mirentxu Santos
Journal:  Proc Natl Acad Sci U S A       Date:  2019-10-14       Impact factor: 11.205

8.  Identification of cancer initiating cells in K-Ras driven lung adenocarcinoma.

Authors:  Sara Mainardi; Nieves Mijimolle; Sarah Francoz; Carolina Vicente-Dueñas; Isidro Sánchez-García; Mariano Barbacid
Journal:  Proc Natl Acad Sci U S A       Date:  2013-12-23       Impact factor: 11.205
  8 in total
  1 in total

1.  Pten and p53 Loss in the Mouse Lung Causes Adenocarcinoma and Sarcomatoid Carcinoma.

Authors:  Sara Lázaro; Corina Lorz; Ana Belén Enguita; Iván Seller; Jesús M Paramio; Mirentxu Santos
Journal:  Cancers (Basel)       Date:  2022-07-28       Impact factor: 6.575
  1 in total

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