INTRODUCTION: Both beta-amyloid (Ab) deposition and decline in white matter integrity, are brain alterations observed in Alzheimer's disease (AD) and start to occur by the fourth and fifth decades. However, the association between both brain alterations in asymptomatic subjects is unclear. METHODS: Amyloid positron emission tomography (PET) and diffusion tensor imaging (DTI) were obtained in 282 cognitively normal subjects (age 30-89 years). We assessed the interaction of age by abnormal amyloid PET status (Florbetapir F-18 PET >1.2 standard uptake value ratio [SUVR]) on regional mean diffusivity (MD) and global white matter hyperintensity (WMH) volume, controlled for sex, education, and hypertension. RESULTS: Subjects with abnormal amyloid PET (n = 87) showed stronger age-related increase in global WMH and regional MD, particularly within the posterior parietal regions of the white matter. DISCUSSION: Sporadic Aβ deposition is associated with white matter alterations in AD predilection areas in an age-dependent manner in cognitively normal individuals.
INTRODUCTION: Both beta-amyloid (Ab) deposition and decline in white matter integrity, are brain alterations observed in Alzheimer's disease (AD) and start to occur by the fourth and fifth decades. However, the association between both brain alterations in asymptomatic subjects is unclear. METHODS: Amyloid positron emission tomography (PET) and diffusion tensor imaging (DTI) were obtained in 282 cognitively normal subjects (age 30-89 years). We assessed the interaction of age by abnormal amyloid PET status (Florbetapir F-18 PET >1.2 standard uptake value ratio [SUVR]) on regional mean diffusivity (MD) and global white matter hyperintensity (WMH) volume, controlled for sex, education, and hypertension. RESULTS: Subjects with abnormal amyloid PET (n = 87) showed stronger age-related increase in global WMH and regional MD, particularly within the posterior parietal regions of the white matter. DISCUSSION: Sporadic Aβ deposition is associated with white matter alterations in AD predilection areas in an age-dependent manner in cognitively normal individuals.
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Authors: Sofia Finsterwalder; Naomi Vlegels; Benno Gesierich; Miguel Á Araque Caballero; Nick A Weaver; Nicolai Franzmeier; Marios K Georgakis; Marek J Konieczny; Huiberdina L Koek; Celeste M Karch; Neill R Graff-Radford; Stephen Salloway; Hwamee Oh; Ricardo F Allegri; Jasmeer P Chhatwal; Frank Jessen; Emrah Düzel; Laura Dobisch; Coraline Metzger; Oliver Peters; Enise I Incesoy; Josef Priller; Eike J Spruth; Anja Schneider; Klaus Fließbach; Katharina Buerger; Daniel Janowitz; Stefan J Teipel; Ingo Kilimann; Christoph Laske; Martina Buchmann; Michael T Heneka; Frederic Brosseron; Annika Spottke; Nina Roy; Birgit Ertl-Wagner; Klaus Scheffler; Sang Won Seo; Yeshin Kim; Duk L Na; Hee Jin Kim; Hyemin Jang; Michael Ewers; Johannes Levin; Reinhold Schmidt; Ofer Pasternak; Martin Dichgans; Geert Jan Biessels; Marco Duering Journal: Alzheimers Dement Date: 2020-08-18 Impact factor: 21.566
Authors: Sheelakumari Raghavan; Robert I Reid; Scott A Przybelski; Timothy G Lesnick; Jonathan Graff-Radford; Christopher G Schwarz; David S Knopman; Michelle M Mielke; Mary M Machulda; Ronald C Petersen; Clifford R Jack; Prashanthi Vemuri Journal: Brain Commun Date: 2021-05-19