Min Peng1, Xiang Li2, Yujing Liu2, Min Zou3, Yaqian Xia2, Gelin Xu1,2. 1. Department of Neurology, Jinling Hospital, Medical School of Nanjing University. 2. Department of Neurology, Jinling Hospital, Jinling Clinical College of Nanjing Medical University. 3. Department of Hematology, Xiangtan City Central Hospital.
Abstract
AIM: Glycemic index (GI) and glycemic load (GL) influence postprandi al glucose concentrations and insulin responses. This study aims to ascertain the connection between GI, GL, and carotid atherosclerotic stenosis and cardiovascular disease (CVD) risk factors. METHODS: A total of 669 patients with ischemic stroke within 7 days were enrolled. GI and GL were assessed with a validated food frequency questionnaire from patients. Computed tomography angiography (CTA) was used for the evaluation of carotid atherosclerotic stenosis. Traditional risk factors such as total cholesterol, triglycerides, LDL-C, HDL-C, C-reactive protein, homocysteine, neutrophil to lymphocyte ratio (NLR), fasting plasma glucose, and hemoglobin A1c were measured. GI/GL and its association with CVD risk factors and carotid stenosis were explored with Spearman analysis and multivariable logistic regression, respectively. RESULTS: The prevalence of carotid stenosis was 63.2% of all 669 participants. The mean value of GI/GL was 49.3/137. Spearman test did not detect significant relationships between GI/GL and CVD risk factors. In multivariable regression models, GI (4th vs. 1st quartile, OR=2.11; 95% CI, 1.30-3.42) and GL (4th vs. 1st quartile, OR=1.82; 95% CI, 1.12-2.96) were observed a significant association with carotid stenosis after adjustment for major confounding factors. The association between GL and carotid stenosis became more pronounced among yo ungers (4th vs. 1st quartile, OR=2.42; 95% CI, 1.13-4.76) and women (4th vs. 1st quartile, OR=3.81; 95% CI, 1.45-5.05). CONCLUSION: Higher GI and GL were positively associated with a higher degree of carotid stenosis in these Chinese cerebral infarction patients, especially in younger patients and women.
AIM: Glycemic index (GI) and glycemic load (GL) influence postprandi al glucose concentrations and insulin responses. This study aims to ascertain the connection between GI, GL, and carotid atherosclerotic stenosis and cardiovascular disease (CVD) risk factors. METHODS: A total of 669 patients with ischemic stroke within 7 days were enrolled. GI and GL were assessed with a validated food frequency questionnaire from patients. Computed tomography angiography (CTA) was used for the evaluation of carotid atherosclerotic stenosis. Traditional risk factors such as total cholesterol, triglycerides, LDL-C, HDL-C, C-reactive protein, homocysteine, neutrophil to lymphocyte ratio (NLR), fasting plasma glucose, and hemoglobin A1c were measured. GI/GL and its association with CVD risk factors and carotid stenosis were explored with Spearman analysis and multivariable logistic regression, respectively. RESULTS: The prevalence of carotid stenosis was 63.2% of all 669 participants. The mean value of GI/GL was 49.3/137. Spearman test did not detect significant relationships between GI/GL and CVD risk factors. In multivariable regression models, GI (4th vs. 1st quartile, OR=2.11; 95% CI, 1.30-3.42) and GL (4th vs. 1st quartile, OR=1.82; 95% CI, 1.12-2.96) were observed a significant association with carotid stenosis after adjustment for major confounding factors. The association between GL and carotid stenosis became more pronounced among yo ungers (4th vs. 1st quartile, OR=2.42; 95% CI, 1.13-4.76) and women (4th vs. 1st quartile, OR=3.81; 95% CI, 1.45-5.05). CONCLUSION: Higher GI and GL were positively associated with a higher degree of carotid stenosis in these Chinese cerebral infarctionpatients, especially in younger patients and women.
Authors: Frank M Sacks; Vincent J Carey; Cheryl A M Anderson; Edgar R Miller; Trisha Copeland; Jeanne Charleston; Benjamin J Harshfield; Nancy Laranjo; Phyllis McCarron; Janis Swain; Karen White; Karen Yee; Lawrence J Appel Journal: JAMA Date: 2014-12-17 Impact factor: 56.272
Authors: D J Jenkins; T M Wolever; R H Taylor; H Barker; H Fielden; J M Baldwin; A C Bowling; H C Newman; A L Jenkins; D V Goff Journal: Am J Clin Nutr Date: 1981-03 Impact factor: 7.045
Authors: H J M Barnett; D W Taylor; R B Haynes; D L Sackett; S J Peerless; G G Ferguson; A J Fox; R N Rankin; V C Hachinski; D O Wiebers; M Eliasziw Journal: N Engl J Med Date: 1991-08-15 Impact factor: 91.245
Authors: Arash Mirrahimi; Laura Chiavaroli; Korbua Srichaikul; Livia S A Augustin; John L Sievenpiper; Cyril W C Kendall; David J A Jenkins Journal: Curr Atheroscler Rep Date: 2014-01 Impact factor: 5.113