Literature DB >> 32145087

Experimental verification the electron return effect around spherical air cavities for the MR-Linac using Monte Carlo calculation.

J Shortall1, E Vasquez Osorio1, A Aitkenhead1,2, J Berresford2, J Agnew2, G Budgell1,2, R Chuter1,2, A McWilliam1,2, K Kirkby1,2, R Mackay1,2, M van Herk1,2.   

Abstract

PURPOSE: Dose deposition around unplanned air cavities during magnetic resonance-guided radiotherapy (MRgRT) is influenced by the electron return effect (ERE). This is clinically relevant for gas forming close to or inside organs at risk (OARs) that lie in the path of a single beam, for example, intestinal track during pelvic treatment. This work aims to verify Monte Carlo calculations that predict the dosimetric effects of ERE around air cavities. For this, we use GafChromic EBT3 film inside poly-methyl methacrylate (PMMA) -air phantoms.
METHOD: Four PMMA phantoms were produced. Three of the phantoms contained centrally located spherical air cavities (0.5, 3.5, 7.5 cm diameter), and one phantom contained no air. The phantoms were split to sandwich GafChromic EBT3 film in the center. The phantoms were irradiated on an Elekta Unity system using a single 10 × 10 cm2 7-MV photon beam under the influence of a 1.5-T transverse magnetic field. The measurements were replicated using the Elekta Monaco treatment planning system (TPS). Gamma analysis with pass criteria 3%/3 mm was used to compare the measured and calculated dose distributions. We also consider 3%/2 mm, 2%/3 mm, and 2%/2 mm pass criteria for interest.
RESULTS: The gamma analysis showed that >95% of the points agreed between the TPS-calculated and measured dose distributions, using 3%/3 mm criteria. The phantom containing the largest air cavity had the lowest agreement, with most of the disagreeing points lying inside the air cavity (dose to air region).
CONCLUSIONS: The dose effects due to ERE around spherical air cavities are being calculated in the TPS with sufficient accuracy for clinical use.
© 2020 American Association of Physicists in Medicine.

Entities:  

Keywords:  IGRT; Image-guided radiotherapy; MR-guided radiotherapy; MRgRT; Radiotherapy; cancer; dose; experimental dosimetry

Mesh:

Year:  2020        PMID: 32145087     DOI: 10.1002/mp.14123

Source DB:  PubMed          Journal:  Med Phys        ISSN: 0094-2405            Impact factor:   4.071


  3 in total

1.  Commissioning a secondary dose calculation software for a 0.35 T MR-linac.

Authors:  Alex T Price; Nels C Knutson; Taeho Kim; Olga L Green
Journal:  J Appl Clin Med Phys       Date:  2022-02-15       Impact factor: 2.102

2.  Emergence of MR-Linac in Radiation Oncology: Successes and Challenges of Riding on the MRgRT Bandwagon.

Authors:  Indra J Das; Poonam Yadav; Bharat B Mittal
Journal:  J Clin Med       Date:  2022-08-31       Impact factor: 4.964

3.  Dosimetric Effects of Air Cavities for MRI-Guided Online Adaptive Radiation Therapy (MRgART) of Prostate Bed after Radical Prostatectomy.

Authors:  Jonathan Pham; Minsong Cao; Stephanie M Yoon; Yu Gao; Amar U Kishan; Yingli Yang
Journal:  J Clin Med       Date:  2022-01-12       Impact factor: 4.241

  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.