Bindi B Parikh1, Elizabeth C Neil2. 1. Department of Neurology, University of Minnesota, 516 Delaware St SE, 12-100 Phillips Wangensteen Building, Minneapolis, MN, 55455, USA. 2. Department of Neurology, University of Minnesota, 516 Delaware St SE, 12-100 Phillips Wangensteen Building, Minneapolis, MN, 55455, USA. neile@umn.edu.
Abstract
PURPOSE OF REVIEW: Provide an overview, the indications for use, and a synopsis of current literature regarding two evolving neurosurgical interventions-GammaTile therapy (GTT) and laser interstitial thermal therapy (LITT). RECENT FINDINGS: GTT delivers immediate, uniform, high-dose radiation with avoidance of direct brain-to-seed contact. Innate properties of the novel carrier system and cesium-131 source may explain lower observed rate of radiation-induced necrosis (RIN) and support use in larger and previously irradiated lesions. LITT delivers focal laser energy to cause heat-generated necrosis. Case series suggest use in difficult-to-access lesions and treatment of RIN. Collaboration among subspecialties and remaining up-to-date on evolving technology is critical in developing individualized treatment plans for patients with brain cancer. While patients should be thoroughly counseled that these interventions are not standard of care, in optimal clinical scenarios, GTT and LITT could extend quantity and quality of life for patients with few remaining options. Prospective studies are needed to establish specific treatment parameters.
PURPOSE OF REVIEW: Provide an overview, the indications for use, and a synopsis of current literature regarding two evolving neurosurgical interventions-GammaTile therapy (GTT) and laser interstitial thermal therapy (LITT). RECENT FINDINGS: GTT delivers immediate, uniform, high-dose radiation with avoidance of direct brain-to-seed contact. Innate properties of the novel carrier system and cesium-131 source may explain lower observed rate of radiation-induced necrosis (RIN) and support use in larger and previously irradiated lesions. LITT delivers focal laser energy to cause heat-generated necrosis. Case series suggest use in difficult-to-access lesions and treatment of RIN. Collaboration among subspecialties and remaining up-to-date on evolving technology is critical in developing individualized treatment plans for patients with brain cancer. While patients should be thoroughly counseled that these interventions are not standard of care, in optimal clinical scenarios, GTT and LITT could extend quantity and quality of life for patients with few remaining options. Prospective studies are needed to establish specific treatment parameters.
Authors: Alexandre Carpentier; Roger J McNichols; R Jason Stafford; Jean-Pierre Guichard; Daniel Reizine; Suzette Delaloge; Eric Vicaut; Didier Payen; Ashok Gowda; Bernard George Journal: Lasers Surg Med Date: 2011-11-22 Impact factor: 4.025
Authors: A Gabriella Wernicke; Menachem Z Yondorf; Bhupesh Parashar; Dattatreyudu Nori; K S Clifford Chao; John A Boockvar; Susan Pannullo; Philip Stieg; Theodore H Schwartz Journal: J Neurooncol Date: 2016-01-02 Impact factor: 4.130
Authors: Lesley A Jarvis; Nathan E Simmons; Marc Bellerive; Kadir Erkmen; Clifford J Eskey; David J Gladstone; Eugen B Hug; David W Roberts; Alan C Hartford Journal: Int J Radiat Oncol Biol Phys Date: 2012-04-09 Impact factor: 7.038
Authors: David R Raleigh; Zachary A Seymour; Bryan Tomlin; Philip V Theodosopoulos; Mitchel S Berger; Manish K Aghi; Sarah E Geneser; Devan Krishnamurthy; Shannon E Fogh; Penny K Sneed; Michael W McDermott Journal: J Neurosurg Date: 2016-07-01 Impact factor: 5.115
Authors: Christina I Armpilia; Roger G Dale; Ian P Coles; Bleddyn Jones; Vassilis Antipas Journal: Int J Radiat Oncol Biol Phys Date: 2003-02-01 Impact factor: 7.038
Authors: Paolo Palmisciano; Ali S Haider; Kishore Balasubramanian; Randy S D'Amico; Alla Gabriella Wernicke Journal: J Neurooncol Date: 2022-06-13 Impact factor: 4.506